TY - JOUR AU - Shelef, Miriam A. AU - Bennin, David A. AU - Mosher, Deane F. AU - Huttenlocher, Anna PY - 2012 DA - 2012/11/05 TI - Citrullination of fibronectin modulates synovial fibroblast behavior JO - Arthritis Research & Therapy SP - R240 VL - 14 IS - 6 AB - Rheumatoid arthritis is an autoimmune arthritis characterized by joint destruction. Anti-citrullinated protein antibodies are pathologic in rheumatoid arthritis, but the role of the citrullinated proteins themselves is much less clear. Citrullination is the conversion of the arginine residues of a protein to citrulline. In the inflamed rheumatoid joint there is increased protein citrullination. Several proteins are citrullinated in rheumatoid arthritis, including collagen type II, fibrinogen, and fibronectin. Fibronectin is thought to mediate the adhesion of joint-invading synovial fibroblasts to the rheumatoid cartilage in addition to regulating other synovial fibroblast functions. However, the effect of citrullinated fibronectin on synovial fibroblasts is unknown. SN - 1478-6354 UR - https://doi.org/10.1186/ar4083 DO - 10.1186/ar4083 ID - Shelef2012 ER -