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Table 1 Effects of 1,000 μmol/l sodium ferulate on apoptosis-related gene expression in rat osteoarthritis chondrocytes.

From: TNF/TNFR signal transduction pathway-mediated anti-apoptosis and anti-inflammatory effects of sodium ferulate on IL-1β-induced rat osteoarthritis chondrocytes in vitro

Gene Model control/normal control (20 ng/ml vs. 0 ng/ml IL-1β) SF treatment/model control (1,000 μmol/l vs. 0 μmol/l SF in presence of 20 ng/ml IL-1β)
TNF/TNFR pathway   
   TNF 30.07 0.64
   TNFR-1b 3.04 0.39
   TRAF-2 2.50 0.43
   TRADD 1.98 0.69
   Caspase-8 2.30 0.43
   Caspase-3 1.88 0.46
   NF-κB 2.55 0.56
Other pathways   
   Fas 1.85 1.00
   Fas ligand 0.45 0.42
   FADD 0.94 0.58
   Bcl-2 0.75 0.59
   Bax 0.61 0.66
   Bax/Bcl-2 0.80 1.12
   Apaf1 0.76 1.03
   Caspase 9 0.53 0.48
  1. Each reported value represents the mean fold of mRNA expression relative to the control levels for three biological replicates. FADD, Fas-associated death domain protein; SF, sodium ferulate; TNFR, tumor necrosis factor receptor; TRADD, TNF receptor-associated death domain; TRAF, TNF receptor-associated factor.