Treatment of B6.Sle1.Sle3 mice with PCI-32765 results in reduction of splenomegaly. (A) PCI-32765 has no effect on mouse weight. All mice were weighed before sacrifice. (B-C) PCI-32765 reduces splenomegaly, but not kidney size, as measured by weight or cell number. Spleens and kidneys isolated from mice treated with PCI-32765 (n = 9) or vehicle (n = 8) were weighed prior to the creation of a single cell suspension of each tissue. Cells were then counted on a Cellometer Auto M10 automated cell counter (Nexcelom Bioscience). Each data point represents one mouse. Line represents mean ± standard error of the mean. *P < 0.05, **P < 0.005. Data were compared by two-tailed Student's t-test with Welch's correction.