Table 1 Analysis of surface phenotype of splenocytes
| Â | Cell Number/Spleen | Â | |||
|---|---|---|---|---|---|
B cells | Average Vehicle | SEM Vehicle | Average PCI-32765 | SEM PCI-32765 | P-value |
B220+ | 3.97E+07 | 1.13E+07 | 9.06E+06 | 2.76E+06 | * |
Activated, B220+CD69+ | 3.71E+06 | 9.33E+05 | 5.29E+05 | 9.19E+04 | ** |
T1, B220+AA4.1+CD23- | 1.64E+07 | 5.90E+06 | 2.95E+06 | 8.72E+05 | * |
T2, B220+AA4.1+CD23+ | 1.60E+07 | 3.42E+06 | 4.02E+06 | 1.79E+06 | ** |
Marginal zone, B220+AA4.1-CD23- | 1.99E+06 | 5.05E+05 | 5.25E+05 | 1.92E+05 | * |
Follicular, B220+AA4.1-CD23+ | 5.13E+06 | 1.89E+06 | 8.82E+05 | 2.18E+05 | * |
Plasmablast, B220+AA4.1-CD138+ | 3.62E+06 | 9.24E+05 | 4.36E+05 | 7.13E+04 | ** |
Germinal center, B220+GL7+ | 8.61E+06 | 4.52E+06 | 8.72E+05 | 3.38E+05 | NS |
B1-like, B220+CD5+ | 1.01E+06 | 2.62E+05 | 2.60E+05 | 3.93E+04 | * |
Myeloid | Â | Â | Â | Â | Â |
Myeloid DC, CD11b+CD11c+ | 1.33E+07 | 2.76E+06 | 2.19E+06 | 4.28E+05 | *** |
Macrophage, CD11b+F4/80+ | 1.32E+07 | 3.11E+06 | 2.15E+06 | 3.88E+05 | ** |
CD11b+Ly6C+ | 1.74E+06 | 5.54E+05 | 3.40E+05 | 6.72E+04 | * |
Neutrophils, CD11b+Ly6G+ | 1.50E+07 | 3.51E+06 | 2.41E+06 | 4.16E+05 | ** |
Mast cell, CD34+c-Kit+ | 3.74E+06 | 9.87E+05 | 7.36E+05 | 2.54E+05 | * |
T cells | Â | Â | Â | Â | Â |
CD4+ | 2.31E+07 | 4.00E+06 | 9.83E+06 | 9.76E+05 | ** |
Activated, CD4+CD69+ | 8.29E+06 | 1.36E+06 | 2.64E+06 | 1.01E+06 | *** |
Naïve, CD4+CD44-CD62L+ | 9.73E+05 | 2.34E+05 | 5.68E+05 | 9.45E+04 | NS |
Central memory, CD4+CD44+CD62L+ | 5.11E+06 | 7.89E+05 | 2.84E+06 | 3.49E+05 | * |
Effector memory, CD4+CD44+CD62L- | 1.56E+07 | 3.04E+06 | 6.00E+06 | 7.58E+05 | ** |
CD8+ | 2.01E+07 | 3.86E+06 | 5.29E+06 | 8.23E+05 | ** |
Activated, CD8+CD69+ | 8.57E+06 | 1.60E+06 | 2.54E+06 | 1.17E+06 | ** |
Naïve, CD8+CD44-CD62L+ | 6.18E+03 | 3.33E+03 | 3.34E+03 | 2.65E+03 | NS |
Central memory, CD8+CD44+CD62L+ | 5.64E+06 | 1.38E+06 | 9.08E+05 | 1.65E+05 | ** |
Effector memory, CD8+CD44+CD62L- | 1.45E+07 | 2.87E+06 | 4.38E+06 | 8.23E+05 | ** |