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Table 1 Gene ontology (GO) analysis of genes differentially expressed in control and proteoglycan-induced spondylitis (PGISp) mouse spines

From: Excessive bone formation in a mouse model of ankylosing spondylitis is associated with decreases in Wnt pathway inhibitors

GO category GO term Number of genes LS permutation P-value KS permutation P-value Efron-Tibshirani's GSA test P-value
GO:0002252 immune effector process 225 0.00001 0.00196 < 0.005 (+)
GO:0002376 immune system process 995 0.00001 0.00002 0.005 (+)
GO:0002444 myeloid leukocyte mediated immunity 18 0.00001 0.00179 0.005 (+)
GO:0002682 regulation of immune system process 374 0.00001 0.01936 0.005 (+)
GO:0002684 positive regulation of immune system process 255 0.00001 0.00417 0.005 (+)
GO:0006954 inflammatory response 293 0.00001 0.00007 < 0.005 (+)
GO:0006955 immune response 562 0.00001 0.00001 0.005 (+)
GO:0032963 collagen metabolic process 30 0.00007 0.01778 0.005 (+)
  Osteoblast genes 16 0.00105 0.00005 0.02 (+)
  1. Gene expression levels in a number of inflammatory pathways, as well as an osteoblast gene set are altered in PGISp spine samples. LS, log summary; KS, Kolmogorov-Smirnov summary; GSA, gene set analysis.