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Table 3 Reasons for non-adherence to the treatment advice of the treat-to-target strategy

From: Adherence to a treat-to-target strategy in early rheumatoid arthritis: results of the DREAM remission induction cohort

  Remission
(DAS28 < 2.6)
(n= 553)
Non-remission
(DAS28 ≥ 2.6)
(n= 539)
Tapering off/discontinuing instead of continuing 40 (7.2)  
   Unknown 12  
   Patient wish 3  
   Side effects 19  
   Clinical remission 5  
   Other 1  
Continuing instead of tapering off/discontinuing 34 (6.2) .
   Unknown 23  
   Patient wish 4  
   Active disease 5  
   Other 2  
Intensifying instead of not intensifying* 24 (4.3) .
   Unknown 2  
   Patient wish 2  
   Active disease 20  
Not intensifying* instead of intensifying . 188 (34.9)
   Unknown   29
   Patient wish   13
   Side effects   32
   Clinical remission   106
   Other   8
Other deviations from treatment advice 10 (1.8) 39 (7.2)
   Unknown 5 10
   Patient wish . 2
   Side effects 4 16
   Clinical remission . 2
   Other 1 9
  1. Data are presented of a total of 1097 visits of 100 patients with early rheumatoid arthritis, stratified by remission state according to the Disease Activity Score in 28 joints (DAS28). Values regarding the type of deviation are presented as number (%), values regarding the reasons for non-adherence are presented as number. *Including continuing, tapering off and discontinuing medication.