Figure 2From: Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosisProteinase-3 (PR-3) mRNA is expressed in pneumocytes type I in human lung tissue (arrows). The expression of PR-3 mRNA was detected by nonradioactive in situ hybridization, and the pneumocytes type I were detected by double-labeling with biotin-labeled lectins of Bauhinia purpurea (magnification, 60 × 2.5).Back to article page