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Table 1 Semiquantitative analysis of proteinase-3 mRNA expression in normal lung and Wegener's granulomatosis (WG) lung specimens.

From: Proteinase-3 as the major autoantigen of c-ANCA is strongly expressed in lung tissue of patients with Wegener's granulomatosis

Specimen Normal lung WG lung
1 + ++
2 (+) +++
3 (+) ++
4 + ++
5 + +++
  1. A representative area between 1,000 and 10,000 cells depending on the specimen was defined. In the representative areas, positive cells for PR-3 mRNA were scored in a semiquantitative fashion: -, no positive cells; (+), < 5% of cells positive; +, between 5% and 30% of cells positive; ++, between 30 and 60% of cells positive; +++, > 60% of cells positive.