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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model

Figure 3

Cartilage regeneration after inhibition of endogenously produced IL-6. Cartilage regeneration cultures of three defect (CD) and three osteoarthritic (OA) donors with blockage of endogenous IL-6 with an activity-inhibiting antibody. (a-c) GAG content, GAG release and DNA content after 28 days of culture in IL-6 blocked samples depicted as percent of control samples (mean ± SD); a = P = 0.009. (d) Safranin-O staining of representative CD and OA chondrocyte donors regenerating either without (control; IgG isotype) or with inhibition (anti-IL-6) of endogenous IL-6. Scale bars indicate 50 μm.

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Arthritis Research & Therapy

ISSN: 1478-6362

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