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Figure 5 | Arthritis Research & Therapy

Figure 5

From: Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model

Figure 5

OA cartilage explant culture with inhibition of synovial fluid IL-6 or addition of exogenous IL-6. (a, c) GAG content and GAG release in OA cartilage explants from three donors cultured either in medium only, medium supplemented with 25% OA synovial fluid (SF) or medium with 25% OA synovial fluid in which IL-6 is blocked with an activity-inhibiting antibody (mean ± SD in mg/g); P = 0.06. (b, d) GAG content and GAG release in OA cartilage explants from eight donors cultured in the presence or absence of rhIL-6 (50 ng/mL) with rhIL-6Rα (200 ng/mL).

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