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Table 1 Effect of collagen coating on IL-6 and cartilage matrix production

From: Interleukin-6 is elevated in synovial fluid of patients with focal cartilage defects and stimulates cartilage matrix production in an in vitro regeneration model

  Col I Col II Col ID Col IID P-value
IL-6 (pg/ml) 4,294 ± 2,152 4,604 ± 1,661 4,268 ± 1,446 5,463 ± 1,991 0.543
GAG (μg) 80 ± 24 85 ± 30 77 ± 25 85 ± 34 0.361
GAG release (μg/ml) 408 ± 29 410 ± 35 400 ± 38 498 ± 157 0.412
DNA (μg) 10 ± 1 9 ± 1 10 ± 2 10 ± 1 0.818
  1. No significant differences were observed between type I collagen (Col I), type II collagen (Col II), denatured type I collagen (Col ID) and denatured type II collagen (Col IID) coating on IL-6 production at Day 7, GAG content after 28 days of culture, cumulative GAG release during 28 days of culture and DNA content after 28 days of culture. Results are displayed as mean ± SD.