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Table 2 Longitudinal regression of joint damage and TNFA -308G > A genotype (n = 208)

From: Meta-analysis identified the TNFA -308G > A promoter polymorphism as a risk factor for disease severity in patients with rheumatoid arthritis

Effect Estimate Standard error (estimate) P-value
Intercept 5.8 1.18 < 0.0001
Genotype GA+AA -5.0 1.62 0.0020
Year 1.6 0.38 < 0.0001
Year2 -0.13 0.020 < 0.0001
Genotype GA+AA × year 0.17 0.34 0.61
  1. Shown are the variables in the longitudinal regression analysis over 9 years, with joint erosion score as the dependent variable and TNFA -308G > A or TNFA -308G > A × year as primary dependent variables. Year2 allows for a non-linear course of joint progression score over time. The analysis was corrected for gender, and time-averaged 28-joint disease activity score (DAS28), rheumatoid factor and age were not confounders.