Meta-analysis identified the TNFA -308G > A promoter polymorphism as a risk factor for disease severity in patients with rheumatoid arthritis

Table 2 Longitudinal regression of joint damage and TNFA -308G > A genotype (n = 208)

Effect	Estimate	Standard error (estimate)	P-value
Intercept	5.8	1.18	< 0.0001
Genotype GA+AA	-5.0	1.62	0.0020
Year	1.6	0.38	< 0.0001
Year²	-0.13	0.020	< 0.0001
Genotype GA+AA × year	0.17	0.34	0.61

Shown are the variables in the longitudinal regression analysis over 9 years, with joint erosion score as the dependent variable and TNFA -308G > A or TNFA -308G > A × year as primary dependent variables. Year² allows for a non-linear course of joint progression score over time. The analysis was corrected for gender, and time-averaged 28-joint disease activity score (DAS28), rheumatoid factor and age were not confounders.

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