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Table 1 Overall statistical power of the study for KCNA5 rs10744676 SNP in each analyzed disease subtype at the 5% significance level assuming an additive effect model and a minor allele (rs10744676*C) frequency = 0.10 (MAFCEU)

From: KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor

  Phenotype
Statistical power (%) SSc lcSSc dcSSc ACA+ ATA+ Fib+ PAH+
OR = 0.62 100 100 99 100 96 99 95a
OR = 0.48 100 100 100 100 100 100 100b
OR = 0.79 96 91 67 77 59 71 45c
  1. aReference OR, 0.62, except for the PAH+ group, in which OR = 0.47. bReference OR (lower previously reported 95% CI) = 0.48, except for the PAH+ group, in which OR = 0.32. cReference OR (upper previously reported 95% CI) = 0.79, except for the PAH+ group, in which OR = 0.71. SSc, systemic sclerosis; lcSSc, limited cutaneous systemic sclerosis; dcSSc, diffuse cutaneous systemic sclerosis; ACA+, anti-centromere autoantibody-positive patients; ATA+, anti-topoisomerase autoantibody-positive patients; Fib+, lung fibrosis-positive patients (HRCT); PAH+, pulmonary arterial hypertension-positive patients (right-heart catheterization).