KCNA5 gene is not confirmed as a systemic sclerosis-related pulmonary arterial hypertension genetic susceptibility factor

Table 1 Overall statistical power of the study for KCNA5 rs10744676 SNP in each analyzed disease subtype at the 5% significance level assuming an additive effect model and a minor allele (rs10744676*C) frequency = 0.10 (MAF_CEU)

^aReference OR, 0.62, except for the PAH⁺ group, in which OR = 0.47. ^bReference OR (lower previously reported 95% CI) = 0.48, except for the PAH⁺ group, in which OR = 0.32. ^cReference OR (upper previously reported 95% CI) = 0.79, except for the PAH⁺ group, in which OR = 0.71. SSc, systemic sclerosis; lcSSc, limited cutaneous systemic sclerosis; dcSSc, diffuse cutaneous systemic sclerosis; ACA⁺, anti-centromere autoantibody-positive patients; ATA⁺, anti-topoisomerase autoantibody-positive patients; Fib⁺, lung fibrosis-positive patients (HRCT); PAH⁺, pulmonary arterial hypertension-positive patients (right-heart catheterization).

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