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Table 1 Clinically significant upper- and lower-GI events (CSULGIEs) composite end point

From: Patient-level pooled analysis of adjudicated gastrointestinal outcomes in celecoxib clinical trials: meta-analysis of 51,000 patients enrolled in 52 randomized trials

With lesion Without lesion
GD hemorrhage Acute hemorrhage of unknown origin, including presumed small bowel hemorrhage
Gastric-outlet obstruction Clinically significant anemia of presumed occult GI origin, including possible small bowel blood loss
GD, small-bowel, or large-bowel perforation  
Large-bowel hemorrhage  
Small-bowel hemorrhage  
Small-bowel obstruction  
Clinically significant anemia of defined GI origin  
Symptomatic ulcers  
  1. GD, gastroduodenal; GI, gastrointestinal.