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Figure 2 | Arthritis Research & Therapy

Figure 2

From: The potential of human regulatory T cells generated ex vivo as a treatment for lupus and other chronic inflammatory diseases

Figure 2

The role of transforming growth factor-β (TGF-β) in the differentiation pathway of CD4+ regulatory T cells. Following T-cell activation where a sufficient amount of IL-2 is produced to overcome the inhibitory effects of TGF-β, the costimulatory effects of this cytokine induce the precursors of CD4+ CD25+ T cells to become contact-dependent 'professional' suppressor cells or induces CD4+ CD25- cells to produce immunosuppressive quantities of TGF-β . IFN, interferon; Tr-1, Treg 1 regulatory CD4+ cells.

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Arthritis Research & Therapy

ISSN: 1478-6362

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