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Table 2 Allelic frequencies of the SNPs studied in the AIRE in RA Spanish patients and controls

From: Association of the AIRE gene with susceptibility to rheumatoid arthritis in a European population: a case control study

SNP
(location)
Allele Controls
2n= 942
Patients
2n= 930
P-value Pc-valuea Odds ratio (95% CI) Japanese populationb
rs2776377
(5'UTR)
A 0.589 0.597 ns    0.265c
rs878081
(exon 5)
C 0.746 0.805 0.0022 0.0123 1.41 (1.13, 1.75) 0.827c
rs2075876
(intron 5)
A 0.114 0.116 ns    0.340d
rs1055311
(exon 6)
T 0.206 0.219 ns    0.012c
rs1800520
(exon 7)
G 0.017 0.019 ns    0.420d
  1. RA, rheumatoid arthritis; SNP, single-nucleotide polymorphism, UTR: unstranlated region, ns: not significant at P > 0.05. aP c -value, 10,000-fold permutation testing; bAllelic frequencies in the Japanese population; cHapMap Project, JPT (Japanese in Tokyo) population; dTerao et al. 2011 [4].