Anti-cyclic citrullinated peptide antibody titer predicts time to rheumatoid arthritis onset in patients with undifferentiated arthritis: results from a 2-year prospective study

Table 4 Risk of developing rheumatoid arthritis: Cox regression univariate and multivariate hazards ratio (HR) analysis

	HR (95% CI) Unadjusted	P	HR (95% CI) Adjusted	P
CRP
Negative	1		1
Low +	0.720 (0.362, 1.434)	0.350	0.875 (0.423, 1.811)	0.719
High+	1.737 (1.049, 2.877)	0.032	1.827 (0.950, 3.514)	0.071
RF
Negative	1		1
Low+	2.020 (1.001, 4.073)	0.050	0.791 (0.248, 2.522)	0.692
High+	3.097 (1.867, 5.137)	< 0.001	0.729 (0.219, 2.431)	0.607
ACPA
Negative	1		1
Low +	3.360 (1.412, 7.998)	0.006	3.187 (1.257, 8.077)	0.015
High +	4.613 (2.698, 7.887)	< 0.001	4.324 (2.023, 9.245)	< 0.001
Hand joints arthritis	1.871 (1.083, 3.232)	0.025	2.140 (1.128, 4.059)	0.020

CRP, C-reactive protein; RF, rheumatoid factor; ACPA, anti-citrullinated peptide antibodies.

ISSN: 1478-6362