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Table 4 Different relation between HOMA-IR index and proinsulin metabolites in controls and patients.

From: Impaired beta cell function is present in nondiabetic rheumatoid arthritis patients

  β coefficient (95% CI)
  Intact proinsulin Intact proinsulin/ Split proinsulin Split proinsulin/
   C-peptide ratio   C-peptide ratio
HOMA-IR index     
   Controls 4.02 (0.66-7.36) 6.23 (1.41-11.06) 10.95 (3.22-18.17) 14.84 (3.99-25.70)
   Patients 0.97 (-0.11-2.06) 0.43 (-0.86-1.71) 6.98 (3.44-10.52) 5.83 (1.40-10.25)
   P valuea 0.36 0.03 0.47 0.23
   RA on GC 1.28 (-0.42-2.98) 0.39 (-1.66-2.44) 6.94 (3.38-10.50) 5.37 (1.06-9.69)
   RA non on GC 0.74 (-0.82-2.28) 5.55 (-1.26-2.36) 4.95 (-1.29-11.18) 3.70 (-4.13-11.72)
   P valueb 0.63 0.90 0.57 0.72
  1. P value represents the comparison of β coefficient between controls and patients (a) and between RA on GC and RA not taking GCs (b) when interaction "HOMAIR × disease" is included in the regression model. HOMA-IR index is considered an independent variable, and proinsulin metabolites as dependent variables. Significant associations (P < 0.05) are depicted in bold