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Table 1 Top 25 up- and downregulated genes for the microarray comparison of notochordal cell (NC)-rich nucleus pulposus (NP) (reference) vs. chondrocyte-like cell-(CLC)-rich NP in chondrodystrophic dogs

From: Gene expression profiling of early intervertebral disc degeneration reveals a down-regulation of canonical Wnt signaling and caveolin-1 expression: implications for development of regenerative strategies

Chondrodystrophic dogs: NC-rich NP vs. CLC-rich NP
Total upregulated genes: 1.178 Total downregulated genes: 1,741
Description GO term: biological Process N-fold change P -value
Carboxypeptidase E Protein modification process 8.65 8.65E-05
Transferrin Transferrin transport 8.58 1.56E-02
Ceruloplasmin (ferroxidase) Cellular iron ion homeostasis 7.34 2.02E-03
Frizzled-related protein Negative regulation of canonical Wnt receptor signaling pathway 7.26 4.24E-03
Decorin Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan 7.11 2.00E-02
Cartilage oligomeric matrix protein Anti-apoptosis 7.08 6.69E-05
Serglycin Negative regulation of bone mineralization 6.97 9.64E-03
Lumican Collagen fibril organization 6.88 1.39E-02
Not annotated Not annotated 6.66 1.15E-02
Metallothionein 2A Cellular response to erythropoietin 6.60 5.33E-03
RAN binding protein 3-like Intracellular transport 6.54 4.71E-02
Retinol binding protein 4, plasma Protein complex assembly 6.40 6.79E-04
Cysteine dioxygenase, type I Response to glucagon stimulus 6.30 1.36E-02
Adenylate cyclase 2 Activation of adenylate cyclase activity by G-protein signaling pathway 5.97 3.94E-04
Tetraspanin 13 Not available 5.88 1.95E-02
Microfibrillar associated protein 5 Not available 5.75 1.17E-04
Proteoglycan 4 Cell proliferation 5.61 3.00E-03
S100 calcium binding protein A12 Inflammatory response 5.59 1.15E-02
Phosphotyrosine interaction domain containing 1 Not available 5.57 8.41E-05
Nephronectin Cell differentiation 5.54 2.76E-04
Lysozyme Cell wall macromolecule catabolic process 5.47 2.42E-02
SPARC-like 1 (hevin) Signal transduction 5.34 2.85E-02
Glycoprotein 25L Not available 5.27 5.84E-04
Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 Regulation of proteolysis 5.08 6.92E-04
Sphingomyelin phosphodiesterase, acid-like 3A Sphingomyelin catabolic process 5.01 1.16E-02
Keratin 18 Golgi to plasma membrane CFTR protein transport -12.93 1.44E-03
tRNA-yW synthesizing protein 3 homolog tRNA processing -7.83 9.45E-04
A kinase (PRKA) anchor protein 12 Signal transduction -7.69 7.56E-03
Phospholipase C-like 1 Lipid metabolic process -7.40 9.48E-03
Desmocollin 3 Cell adhesion -7.05 1.40E-03
Myosin, light chain 9, regulatory Regulation of muscle contraction -6.84 1.64E-02
Mitochondrial ribosomal protein S27 Not available -6.76 4.96E-04
Ectonucleotide pyrophosphatase/phosphodiesterase 2 Regulation of cell migration -6.41 9.38E-03
Keratin 19 Cell differentiation involved in embryonic placenta development -6.32 6.00E-03
Plakophilin 2 Carbohydrate metabolic process -6.13 6.02E-04
Tetraspanin 7 Interspecies interaction between organisms -6.01 3.00E-03
Keratin 8 Cytoskeleton organization -5.94 2.60E-02
Nucleosome assembly protein 1-like 1 DNA replication -5.92 1.40E-03
RAB20, member RAS oncogene family Small GTPase mediated signal transduction -5.79 2.91E-03
Caldesmon 1 Positive regulation of protein binding -5.68 3.60E-03
Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 Synaptic transmission -5.64 4.46E-03
Apelin Positive regulation of phosphorylation -5.59 7.66E-03
Sorbin and SH3 domain containing 2 Biological process -5.42 3.39E-03
Phosphatidylcholine transfer protein Cholesterol metabolic process -5.37 1.30E-03
Kv channel interacting protein 1 Synaptic transmission -5.14 < 1.0E-06
Carbonic anhydrase II Carbon utilization -5.07 2.57E-02
Thy-1 cell surface antigen Cytoskeleton organization -4.74 1.10E-02
RAB38, member RAS oncogene family GTP catabolic process -4.71 5.79E-04
Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C Neural tube development -4.58 1.01E-04
Desmocollin 2 Cell adhesion -4.48 9.91E-03
  1. This specific comparison was chosen to illustrate the overall trend in gene regulations observed in early IVD degeneration. For the top 50 up- and downregulations of all performed microarray analyses, see Additional file 4. For brevity, only one Gene Ontology (GO)-term is given for each gene (obtained with bioDBnet [97]).