Chondrodystrophic dogs: NC-rich NP vs. CLC-rich NP | |||
---|---|---|---|
Total upregulated genes: 1.178 | Total downregulated genes: 1,741 | ||
Description | GO term: biological Process | N-fold change | P -value |
Carboxypeptidase E | Protein modification process | 8.65 | 8.65E-05 |
Transferrin | Transferrin transport | 8.58 | 1.56E-02 |
Ceruloplasmin (ferroxidase) | Cellular iron ion homeostasis | 7.34 | 2.02E-03 |
Frizzled-related protein | Negative regulation of canonical Wnt receptor signaling pathway | 7.26 | 4.24E-03 |
Decorin | Peptide cross-linking via chondroitin 4-sulfate glycosaminoglycan | 7.11 | 2.00E-02 |
Cartilage oligomeric matrix protein | Anti-apoptosis | 7.08 | 6.69E-05 |
Serglycin | Negative regulation of bone mineralization | 6.97 | 9.64E-03 |
Lumican | Collagen fibril organization | 6.88 | 1.39E-02 |
Not annotated | Not annotated | 6.66 | 1.15E-02 |
Metallothionein 2A | Cellular response to erythropoietin | 6.60 | 5.33E-03 |
RAN binding protein 3-like | Intracellular transport | 6.54 | 4.71E-02 |
Retinol binding protein 4, plasma | Protein complex assembly | 6.40 | 6.79E-04 |
Cysteine dioxygenase, type I | Response to glucagon stimulus | 6.30 | 1.36E-02 |
Adenylate cyclase 2 | Activation of adenylate cyclase activity by G-protein signaling pathway | 5.97 | 3.94E-04 |
Tetraspanin 13 | Not available | 5.88 | 1.95E-02 |
Microfibrillar associated protein 5 | Not available | 5.75 | 1.17E-04 |
Proteoglycan 4 | Cell proliferation | 5.61 | 3.00E-03 |
S100 calcium binding protein A12 | Inflammatory response | 5.59 | 1.15E-02 |
Phosphotyrosine interaction domain containing 1 | Not available | 5.57 | 8.41E-05 |
Nephronectin | Cell differentiation | 5.54 | 2.76E-04 |
Lysozyme | Cell wall macromolecule catabolic process | 5.47 | 2.42E-02 |
SPARC-like 1 (hevin) | Signal transduction | 5.34 | 2.85E-02 |
Glycoprotein 25L | Not available | 5.27 | 5.84E-04 |
Serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 | Regulation of proteolysis | 5.08 | 6.92E-04 |
Sphingomyelin phosphodiesterase, acid-like 3A | Sphingomyelin catabolic process | 5.01 | 1.16E-02 |
Keratin 18 | Golgi to plasma membrane CFTR protein transport | -12.93 | 1.44E-03 |
tRNA-yW synthesizing protein 3 homolog | tRNA processing | -7.83 | 9.45E-04 |
A kinase (PRKA) anchor protein 12 | Signal transduction | -7.69 | 7.56E-03 |
Phospholipase C-like 1 | Lipid metabolic process | -7.40 | 9.48E-03 |
Desmocollin 3 | Cell adhesion | -7.05 | 1.40E-03 |
Myosin, light chain 9, regulatory | Regulation of muscle contraction | -6.84 | 1.64E-02 |
Mitochondrial ribosomal protein S27 | Not available | -6.76 | 4.96E-04 |
Ectonucleotide pyrophosphatase/phosphodiesterase 2 | Regulation of cell migration | -6.41 | 9.38E-03 |
Keratin 19 | Cell differentiation involved in embryonic placenta development | -6.32 | 6.00E-03 |
Plakophilin 2 | Carbohydrate metabolic process | -6.13 | 6.02E-04 |
Tetraspanin 7 | Interspecies interaction between organisms | -6.01 | 3.00E-03 |
Keratin 8 | Cytoskeleton organization | -5.94 | 2.60E-02 |
Nucleosome assembly protein 1-like 1 | DNA replication | -5.92 | 1.40E-03 |
RAB20, member RAS oncogene family | Small GTPase mediated signal transduction | -5.79 | 2.91E-03 |
Caldesmon 1 | Positive regulation of protein binding | -5.68 | 3.60E-03 |
Potassium voltage-gated channel, delayed-rectifier, subfamily S, member 3 | Synaptic transmission | -5.64 | 4.46E-03 |
Apelin | Positive regulation of phosphorylation | -5.59 | 7.66E-03 |
Sorbin and SH3 domain containing 2 | Biological process | -5.42 | 3.39E-03 |
Phosphatidylcholine transfer protein | Cholesterol metabolic process | -5.37 | 1.30E-03 |
Kv channel interacting protein 1 | Synaptic transmission | -5.14 | < 1.0E-06 |
Carbonic anhydrase II | Carbon utilization | -5.07 | 2.57E-02 |
Thy-1 cell surface antigen | Cytoskeleton organization | -4.74 | 1.10E-02 |
RAB38, member RAS oncogene family | GTP catabolic process | -4.71 | 5.79E-04 |
Sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3C | Neural tube development | -4.58 | 1.01E-04 |
Desmocollin 2 | Cell adhesion | -4.48 | 9.91E-03 |