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Table 1 Aberrant epigenetic machinery in rheumatoid arthritis and systemic lupus erythematosus

From: Perspectives on epigenetic-based immune intervention for rheumatic diseases

Enzyme Alternative symbol Observation Disease setting Cell type Reference
DNMT1   Decreased SLE WBCs [10, 12, 13]
    SLE CD4+ T cells [15]
    RA   
DNMT3B   Decreased SLE WBCs [10]
KAT2B PCAF Increased SLE PBMCs [28]
KAT3A CBP Decreased SLE CD4+ T cells [27]
KAT3B P300 Decreased SLE CD4+ T cells [27]
HDAC1   Increased SLE PBMCs [20]
     FLSs [21]
   Decreased FLS Synovial tissues [22]
HDAC2   Decreased SLE CD4+ T cells [27]
HDAC4   Altered sumoylation RA FLSs [23]
HDAC7   Decreased SLE CD4+ T cells [27]
HDAC9   Increased SLE CD4+ T cells [24]
SIRT1   Increased SLE CD4+ T cells [27]
KMT? SETD6 Decreased RA PBMCs [26]
    JIA   
KMT1B SUV39H2 Decreased SLE CD4+ T cells [27]
KMT6 EZH2 Decreased SLE CD4+ T cells [27]
   Increased RA FLSs [25]
KDM6B JMJD3 Decreased SLE CD4+ T cells [29]
  1. CBP, CREB-binding protein; DNMT, DNA methyltransferase; EZH2, enhancer of Zeste, Drosophila, Homolog 2; FLS, fibroblast-like synoviocyte; HDAC, histone deacetylase; JIA, juvenile idiopathic arthritis; JMJD3, Jumonji domain-containing protein 3; KAT, K-acetyltransferase; KDM6B, lysine-specific demethylase 6B; KMT, K-methyltransferase; PBMC, peripheral blood mononuclear cell; PCAF, p300/CBP-associated factor; RA, rheumatoid arthritis; SETD6, SET domain containing 6; SIRT1, Sirtuin 1; SLE, systemic lupus erythematosus; SUV39H2, suppressor of variegation 3-9, Drosophila, Homolog of, 2; WBC, white blood cell.