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Table 2 Shared toxicities of NSAIDs
| Organ system | Toxicity |
|---|---|
| Gastrointestinal | Dyspepsia |
| Esophagitis | |
| Gastroduodenal ulcers | |
| Ulcer complications (bleeding, perforation obstruction) | |
| Small bowel erosions and strictures | |
| Colitis | |
| Renal | Sodium retention |
| Weight gain and edema | |
| Hypertension | |
| Type IV renal tubular acidosis and hyperkalemia | |
| Acute renal failure | |
| Papillary necrosis | |
| Acute interstitial nephritis | |
| Accelerated chronic kidney disease | |
| Cardiovascular | Heart failure |
| Myocardial infarction | |
| Stroke | |
| Cardiovascular death | |
| Hepatic | Elevated transaminases |
| Asthma/allergic | Aspirin-exacerbated respiratory diseasea (susceptible patients) |
| Rash | |
| Hematologic | Cytopenias |
| Nervous | Dizziness, confusion, drowsiness |
| Seizures | |
| Aseptic meningitis | |
| Bone | Delayed healing |
