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Table 2 Shared toxicities of NSAIDs

From: Use of NSAIDs in treating patients with arthritis

Organ system Toxicity
Gastrointestinal Dyspepsia
  Esophagitis
  Gastroduodenal ulcers
  Ulcer complications (bleeding, perforation obstruction)
  Small bowel erosions and strictures
  Colitis
Renal Sodium retention
  Weight gain and edema
  Hypertension
  Type IV renal tubular acidosis and hyperkalemia
  Acute renal failure
  Papillary necrosis
  Acute interstitial nephritis
  Accelerated chronic kidney disease
Cardiovascular Heart failure
  Myocardial infarction
  Stroke
  Cardiovascular death
Hepatic Elevated transaminases
Asthma/allergic Aspirin-exacerbated respiratory diseasea (susceptible patients)
  Rash
Hematologic Cytopenias
Nervous Dizziness, confusion, drowsiness
  Seizures
  Aseptic meningitis
Bone Delayed healing
  1. Reprinted with permission from [1]. aReduced risk in cyclooxygenase-2-selective NSAIDs