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Figure 1 | Arthritis Research & Therapy

Figure 1

From: Evaluation of the novel folate receptor ligand [18F]fluoro-PEG-folate for macrophage targeting in a rat model of arthritis

Figure 1

Synthesis of [18F]fluoro-PEG-folate. Synthesis of [18F]fluoro-PEG-folate. Conditions: i: [18F]fluoride, acetonitrile, K[2.2.2], K2CO3, 90°C, 10 minutes; ii: a: tetrapropylammonium hydroxide, b: tetramethyl-o-(N-succinimidyl)uranium tetrafluoroborate, 30 to 50% (for i and ii); iii: 150 mM borate buffer, 30 minutes ambient temperature, 70 to 90%.

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