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Table 1 miRNA players in regulation of innate immunity

From: microRNA-mediated regulation of innate immune response in rheumatic diseases

miRNA Target Regulated process References
  Ligand/cytokine Receptor Signaling component Transcription factor Others   
let-7e   TLR4     Endotoxin sensitivity and tolerance [53]
miR-106a IL-10    AML1   Monocyte differentiation, IL-10 production [32, 77]
miR-125b TNFα      TNFα production by macrophages [55]
miR-142-3p IL-6      IL-6 production by DCs [76]
miR-145    MAL    TLR2-mediated and TLR4-mediated signaling [63]
miR-146a    IRAK1, IRAK2, TRAF6 IRF5, STAT1   NF-κB-mediated inflammatory response, type I interferon induction and signaling [3941, 43, 44, 47]
miR-148a/b    CaMKIIα    DC activation/antigen presentation [66]
miR-15    IKKα    Monocyte differentiation [34]
miR-152    CaMKIIα    DC activation/antigen presentation [66]
miR-155    IKKε MyD88 TAB2 PU.1, C/EBPβ, c-Fos KPC1 SOCS1 SHIP1 DC development/maturation granulocyte/monocyte expansion endotoxin sensitivity and tolerance [6, 38, 45, 5060, 92]
     BCL6   NF-κB-mediated inflammatory response, AKT signaling and inflammation, type I interferon induction and signaling  
miR-155*      IRAKM Type I interferon induction [6]
miR-16    IKKα    Monocyte differentiation [34]
miR-17-5p     AML1   Monocyte differentiation [32]
miR-187     IκBζ   IL-10-driven anti-inflammatory response [71]
miR-19a/b   TLR2     TLR2-triggered inflammatory response [73]
miR-200b/c    MyD88    NF-κB-mediated inflammatory response [65]
miR-20a     AML1   Monocyte differentiation [32]
miR-21 JAG1     PDCD4 DC development/maturation, NF-κB-mediated inflammatory response [35, 64]
miR-221      p27 DC development/maturation [36, 59]
miR-223    IKKα, NLRP3 MEF2C STAT3   Monocyte differentiation, granulocyte proliferation/activation, TLR-induced IL-6/IL-1β production [34, 37, 69, 74, 75]
       NLRP3 inflammasome response  
miR-23b    TAB2, TAB3, IKKα    IL-17-triggered, TNFα-triggered, and IL-1β-triggered inflammatory response [67]
miR-29 IFNγ      IFNγ production and NK cell activation [78]
miR-34a JAG1      DC development/maturation [35]
  WNT1       
miR-424     NFI-A   Monocyte differentiation [33]
miR-9     NFKB1   NF-κB-mediated inflammatory response [70]
  1. AML1, acute myeloid leukemia-1; C/EBPβ, CCAAT/enhancer binding protein beta; DC, dendritic cell; IFN, interferon; IRAK, IL-1 receptor-associated kinase; IRF, IFN regulatory factor; IKK, I-kappa-B kinase; MAL, MyD88 adapter-like; NK, natural killer; NLRP3, NLR family PYD-containing protein 3; SHIP1, SH2 domain-containing inositol phosphatase-1; STAT, signal transducer and activator of transcription; TAB, TAK1-binding protein; TLR, toll-like receptor; TRAF, TNF receptor-associated factor.