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Table 4 Regions of interest with significant differences in activation between cSLE patients with versus without neurocognitive dysfunction

From: Functional neuronal network activity differs with cognitive dysfunction in childhood-onset systemic lupus erythematosus

  Anatomical region of interest no-NCD group NCD group p-value
Working memory/N-back Precuneus 1.05 ± 0.17 0.13 ± 0.25 0.004
  Parietal inf L 2.32 ± 0.32 1.10 ± 0.47 0.030
  Parietal inf R 3.22 ± 0.41 1.77 ± 0.59 0.041
Attention/CPT-IP Insula + temporal sup L 0.45 ± 0.19 1.06 ± 0.27 0.050
VCA/match-motor contrast Frontal inf L 0.71 ± 0.12 0.25 ± 0.17 0.032
  Frontal mid L 0.72 ± 0.12 0.26 ± 0.18 0.029
  Frontal sup L 0.50 ± 0.10 0.15 ± 0.14 0.037
  Parietal inf +supramarginal L 1.19 ± 0.16 0.66 ± 0.23 0.050
  Parietal sup L 1.62 ± 0.23 0.81 ± 0.34 0.045
  Fusiform+occipital inf L 1.58 ± 0.27 0.59 ± 0.40 0.038
  Fusiform+occipital inf R 1.49 ± 0.26 0.52 ± 0.39 0.036
VCA/square-motor contrast Frontal sup R 0.54 ± 0.09 0.21 ± 0.13 0.033
  Precuneus bilateral 0.85 ± 0.14 0.34 ± 0.20 0.036
  Fusiform+occipital inf L 1.95 ± 0.24 1.06 ± 0.35 0.033
  Fusiform+occipital inf R 1.54 ± 0.22 0.77 ± 0.33 0.048
  1. Region of interest (ROI) activation is defined as the (sum of T-scores within the ROI among voxels with T-scores > 1.66 that are part of clusters of at least 10 voxels)/total voxels in the ROI. cSLE, childhood-onset systemic lupus erythematosus; NCD, neurocognitive dysfunction; CPT-IP: continuous performance task- identical pairs; VCA, visuoconstructive ability; L, left; R, right; inf, inferior; mid, middle.