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Table 2 Risk estimates for the association of TGFβ1 SNPs with knee OA by being overweight (BMI >25k g/m2)

From: Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis

SNP

Gen

OW

Knee

OA

Contr

Univariate

Adjusted†

Adjusted‡

   

N

N

OR

(95% CI)

P-value

OR

(95% CI)

P-value

OR

(95% CI)

P-value

rs11466321

11

-

83

273

1.00

  

1.00

  

1.00

  
 

12/22

-

16

41

1.28

(0.69, 2.40)

0.436

1.19

(0.62, 2.29)

0.607

1.10

(0.54, 2.22)

0.790

 

11

+

770

548

4.60

(3.52, 6.02)

<0.001

4.84

(3.66, 6.40)

<0.001

4.08

(3.02, 5.52)

<0.001

 

12/22

+

170

98

5.76

(4.06, 8.18)

<0.001

5.75

(4.00, 8.28)

<0.001

4.83

(3.28, 7.11)

<0.001

rs8179181

11

-

11

15

1.00

  

1.00

  

1.00

  
 

12/22

-

87

261

0.45

(0.20, 1.03)

0.058

0.45

(0.19, 1.06)

0.068

0.53

(0.21, 1.29)

0.162

 

11

+

67

49

1.86

(0.79, 4.41)

0.156

1.98

(0.79, 4.93)

0.143

2.03

(0.78, 5.25)

0.147

 

12/22

+

862

617

1.90

(0.87, 4.17)

0.109

1.98

(0.86, 4.57)

0.110

2.01

(0.84, 4.78)

0.115

rs8105161

11

-

2

13

1.00

  

1.00

  

1.00

  
 

12/22

-

96

299

2.09

(0.46, 9.41)

0.338

2.27

(0.49, 10.58)

0.297

2.41

(0.50, 11.57)

0.271

 

11

+

23

18

8.31

(1.66, 41.61)

0.010

9.53

(1.83, 49.78)

0.008

9.41

(1.72, 51.60)

0.010

 

12/22

+

915

623

9.53

(2.14, 42.38)

0.003

10.93

(2.38, 50.21)

0.002

9.86

(2.08, 46.61)

0.004

rs2278422

11

-

28

113

1.00

  

1.00

  

1.00

  
 

12/22

-

68

197

1.39

(0.85, 2.29)

0.191

1.31

(0.78, 2.19)

0.306

1.43

(0.83, 2.48)

0.197

 

11

+

351

182

7.80

(4.97, 12.25)

<0.001

7.57

(4.74, 12.08)

<0.001

6.95

(4.22, 11.47)

<0.001

 

12/22

+

582

462

5.07

(3.29, 7.80)

<0.001

5.28

(3.38, 8.27)

<0.001

4.72

(2.92, 7.64)

<0.001

rs2241718

11

-

3

13

1.00

  

1.00

  

1.00

  
 

12/22

-

93

293

1.38

(0.38, 4.93)

0.625

1.37

(0.37, 5.11)

0.639

1.36

(0.35, 5.24)

0.659

 

11

+

29

25

5.03

(1.28, 19.67)

0.020

5.56

(1.36, 22.75)

0.017

4.86

(1.13, 20.93)

0.034

 

12/22

+

896

607

6.39

(1.81, 22.50)

0.004

6.73

(1.84, 24.66)

0.004

5.71

(1.50, 21.65)

0.010

rs1800468

11

-

82

258

1.00

  

1.00

  

1.00

  
 

12/22

-

15

54

0.87

(0.47, 1.63)

0.672

0.86

(0.45, 1.63)

0.637

0.92

(0.46, 1.84)

0.818

 

11

+

795

551

4.53

(3.45, 5.94)

<0.001

4.75

(3.58, 6.31)

<0.001

4.11

(3.03, 5.56)

<0.001

 

12/22

+

134

90

4.68

(3.25, 6.75)

<0.001

4.98

(3.40, 7.29)

<0.001

4.16

(2.77, 6.24)

<0.001

rs1800469

11

-

7

27

1.00

  

1.00

  

1.00

  
 

12/22

-

91

281

1.25

(0.53, 2.96)

0.614

1.33

(0.54, 3.25)

0.534

1.26

(0.50, 3.19)

0.626

 

11

+

84

59

5.43

(2.22, 13.29)

<0.001

5.97

(2.36, 15.09)

<0.001

5.39

(2.05, 14.12)

0.001

 

12/22

+

846

567

5.75

(2.49, 13.30)

<0.001

6.46

(2.72, 15.39)

<0.001

5.19

(2.11, 12.76)

<0.001

rs1982073

11

-

38

127

1.00

  

1.00

  

1.00

  
 

12/22

-

60

180

1.11

(0.70, 1.77)

0.649

1.13

(0.70, 1.83)

0.612

1.26

(0.75, 2.10)

0.381

 

11

+

351

257

4.56

(3.07, 6.79)

<0.001

4.95

(3.28, 7.47)

<0.001

4.37

(2.82, 6.78)

<0.001

 

12/22

+

569

374

5.07

(3.45, 7.45)

<0.001

5.35

(3.58, 7.97)

<0.001

4.91

(3.20, 7.53)

<0.001

  1. †Adjusted for age and gender; ‡adjusted for age, gender, nodal OA, knee injury, occupational risk factors and bone mineral density (z-score). For OW (overweight), - indicates not overweight, + indicates overweight; TGFβ1, transforming growth factor β1; OA, osteoarthritis; SNP, single nucleotide polymorphism; Gen, genotye; OW, overweight; Contr, controls; OR, odds ratio.
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Arthritis Research & Therapy

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