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Table 2 Risk estimates for the association of TGFβ1 SNPs with knee OA by being overweight (BMI >25k g/m2)

From: Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis

SNP Gen OW Knee
OA
Contr Univariate Adjusted† Adjusted‡
    N N OR (95% CI) P-value OR (95% CI) P-value OR (95% CI) P-value
rs11466321 11 - 83 273 1.00    1.00    1.00   
  12/22 - 16 41 1.28 (0.69, 2.40) 0.436 1.19 (0.62, 2.29) 0.607 1.10 (0.54, 2.22) 0.790
  11 + 770 548 4.60 (3.52, 6.02) <0.001 4.84 (3.66, 6.40) <0.001 4.08 (3.02, 5.52) <0.001
  12/22 + 170 98 5.76 (4.06, 8.18) <0.001 5.75 (4.00, 8.28) <0.001 4.83 (3.28, 7.11) <0.001
rs8179181 11 - 11 15 1.00    1.00    1.00   
  12/22 - 87 261 0.45 (0.20, 1.03) 0.058 0.45 (0.19, 1.06) 0.068 0.53 (0.21, 1.29) 0.162
  11 + 67 49 1.86 (0.79, 4.41) 0.156 1.98 (0.79, 4.93) 0.143 2.03 (0.78, 5.25) 0.147
  12/22 + 862 617 1.90 (0.87, 4.17) 0.109 1.98 (0.86, 4.57) 0.110 2.01 (0.84, 4.78) 0.115
rs8105161 11 - 2 13 1.00    1.00    1.00   
  12/22 - 96 299 2.09 (0.46, 9.41) 0.338 2.27 (0.49, 10.58) 0.297 2.41 (0.50, 11.57) 0.271
  11 + 23 18 8.31 (1.66, 41.61) 0.010 9.53 (1.83, 49.78) 0.008 9.41 (1.72, 51.60) 0.010
  12/22 + 915 623 9.53 (2.14, 42.38) 0.003 10.93 (2.38, 50.21) 0.002 9.86 (2.08, 46.61) 0.004
rs2278422 11 - 28 113 1.00    1.00    1.00   
  12/22 - 68 197 1.39 (0.85, 2.29) 0.191 1.31 (0.78, 2.19) 0.306 1.43 (0.83, 2.48) 0.197
  11 + 351 182 7.80 (4.97, 12.25) <0.001 7.57 (4.74, 12.08) <0.001 6.95 (4.22, 11.47) <0.001
  12/22 + 582 462 5.07 (3.29, 7.80) <0.001 5.28 (3.38, 8.27) <0.001 4.72 (2.92, 7.64) <0.001
rs2241718 11 - 3 13 1.00    1.00    1.00   
  12/22 - 93 293 1.38 (0.38, 4.93) 0.625 1.37 (0.37, 5.11) 0.639 1.36 (0.35, 5.24) 0.659
  11 + 29 25 5.03 (1.28, 19.67) 0.020 5.56 (1.36, 22.75) 0.017 4.86 (1.13, 20.93) 0.034
  12/22 + 896 607 6.39 (1.81, 22.50) 0.004 6.73 (1.84, 24.66) 0.004 5.71 (1.50, 21.65) 0.010
rs1800468 11 - 82 258 1.00    1.00    1.00   
  12/22 - 15 54 0.87 (0.47, 1.63) 0.672 0.86 (0.45, 1.63) 0.637 0.92 (0.46, 1.84) 0.818
  11 + 795 551 4.53 (3.45, 5.94) <0.001 4.75 (3.58, 6.31) <0.001 4.11 (3.03, 5.56) <0.001
  12/22 + 134 90 4.68 (3.25, 6.75) <0.001 4.98 (3.40, 7.29) <0.001 4.16 (2.77, 6.24) <0.001
rs1800469 11 - 7 27 1.00    1.00    1.00   
  12/22 - 91 281 1.25 (0.53, 2.96) 0.614 1.33 (0.54, 3.25) 0.534 1.26 (0.50, 3.19) 0.626
  11 + 84 59 5.43 (2.22, 13.29) <0.001 5.97 (2.36, 15.09) <0.001 5.39 (2.05, 14.12) 0.001
  12/22 + 846 567 5.75 (2.49, 13.30) <0.001 6.46 (2.72, 15.39) <0.001 5.19 (2.11, 12.76) <0.001
rs1982073 11 - 38 127 1.00    1.00    1.00   
  12/22 - 60 180 1.11 (0.70, 1.77) 0.649 1.13 (0.70, 1.83) 0.612 1.26 (0.75, 2.10) 0.381
  11 + 351 257 4.56 (3.07, 6.79) <0.001 4.95 (3.28, 7.47) <0.001 4.37 (2.82, 6.78) <0.001
  12/22 + 569 374 5.07 (3.45, 7.45) <0.001 5.35 (3.58, 7.97) <0.001 4.91 (3.20, 7.53) <0.001
  1. †Adjusted for age and gender; ‡adjusted for age, gender, nodal OA, knee injury, occupational risk factors and bone mineral density (z-score). For OW (overweight), - indicates not overweight, + indicates overweight; TGFβ1, transforming growth factor β1; OA, osteoarthritis; SNP, single nucleotide polymorphism; Gen, genotye; OW, overweight; Contr, controls; OR, odds ratio.