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Table 4 Significant results from gene-environment interactions of TGFβ1 SNPs and BMI in OA

From: Gene-environment interaction between body mass index and transforming growth factor beta 1 (TGFβ1) gene in knee and hip osteoarthritis

TGFβ1SNP OA phenotyp Interaction Univariate Adjusted‡ OR
    ORINT (95% CI) P-Value (LRT) ORINT (95% CI) P-Value (LRT)
rs11466321 Knee OA Multiplicative 0.96 (0.49, 1.91) 0.911 1.08 (0.50, 2.31) 0.851
   RERI 4.25 (2.46, 6.05)   0.67 (-0.92, 2.26)  
   AP 0.75 (0.59, 0.90)   0.14 (-0.16, 0.44)  
   Synergy Index 10.46 (1.42, 77.30)   1.21 (0.77, 1.89)  
rs2278422§ Knee OA Multiplicative 0.47 (0.27, 0.81) 0.005 0.47 (0.26, 0.86) 0.013
   RERI -3.09 (-5.37, -0.81)   -2.66 (-4.96, -0.36)  
   AP -0.61 (-0.95, -0.27)   -0.56 (-0.94, -0.17)  
   Synergy Index 0.57 (0.45, 0.72)   0.59 (0.44, 0.78)  
rs1800468¶ Hip OA Multiplicative 2.78 (1.46, 5.30) 0.001 2.27 (1.15, 4.48) 0.015
   RERI 1.06 (0.38, 1.75)   0.93 (0.19, 1.67)  
   AP 0.46 (0.24, 0.68)   0.42 (0.16, 0.68)  
   Synergy Index 5.32 (0.72, 39.11)   4.33 (0.59, 31.96)  
  1. ‡Adjusted for age, gender, nodal OA, joint injury, occupational risk factors and bone mineral density (z-score). §Statistically significant with RERI <0, AP <0, and synergy index (SI) <1 indicating an antagonistic interaction. Statistically significant with RERI >0, AP >0, and SI >1, indicating a synergetic interaction. TGFβ1, transforming growth factor β1; SNP, single nucleotide polymorphism; BMI, body mass index; OA, osteoarthritis; OR, odds ratio; ORINT, odds ratio for interaction; LRT, likelihood ratio test; RERI, relative excess risk due to interaction; AP, attributable proportion.