Figure 4From: Open label study of escalating doses of oral treprostinil diethanolamine in patients with systemic sclerosis and digital ischemia: pharmacokinetics and correlation with digital perfusionPerfusion area under the curve (AUC) versus concentration AUC. Increased plasma concentrations were observed with increases in treprostinil diethanolamine SR dose. An increase in perfusion was observed with an increase in drug exposure. SR, sustained release.Back to article page