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Table 1 Characteristics of the 60 patients with systemic sclerosis included in the discovery cohort

From: Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis

Age (years), median (range) 53.5 (28-81)
Disease duration (years), median (range) 9 (1-50)
Limited/Diffuse cutaneous subset, n (%) 36 (60)/24 (40)
Modified Rodnan skin score > 14, n (%) 19 (32)
History of digital ulcers, n (%) 29 (47)
Pulmonary fibrosis on CT scan, n (%) 28 (47)
Pulmonary arterial hypertension on RHC, n (%) 4 (7)
Positive antinuclear antibodies (> 1/160), n (%) 53 (88)
Positive antitopoisomerase-1 antibodies, n (%) 28 (47)
Positive anticentromere antibodies, n (%) 12 (20)
FVC < 75% predicted, n (%) 13 (22)
DLCO/AV < 75% predicted, n (%) 23 (38)
Treatment with calcium channel blockers, n (%) 60 (100)
Treatment with angiotensin-converting enzyme inhibitors, n (%) 19 (32)
Treatment with endothelin-receptor antagonists and/or PDE5 inhibitors, n (%) 12 (20)
  1. DLCO/AV, diffusing capacity for carbon monoxide/alveolar volume; FVC, forced vital capacity; PDE5, phosphodiesterase type 5; RHC, right heart catheterization.