Table 2 Nailfold videocapillaroscopy patterns and endothelial marker levels in peripheral blood or serum of patients with systemic sclerosis included in the discovery cohort
From: Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis
Capillaroscopy pattern | P value | |||
|---|---|---|---|---|
Early Median (range) | Active Median (range) | Late Median (range) | ||
EPCs (106 Lin-mononuclear cells) | 61 (29-573) | 82 (21-300) | 31 (5-300) | < 0.0001 |
CECs (106 Lin-mononuclear cells) | 81 (10-342) | 36 (5-155) | 77 (6-472) | 0.4 |
VEGF (pg/ml) | 518 (161-1,028) | 493 (156-1,146) | 814 (189-1,564) | 0.01 |
PlGF (pg/ml) | 9.6 (4.6-24.2) | 9.9 (0.7-19.6) | 10.5 (2.3-26.5) | 0.8 |
sVCAM-1 (ng/ml) | 766 (482-1,828) | 694 (354-1,405) | 767 (459-1,314) | 0.4 |
Tie-2 (ng/ml) | 24.4 (12.9-29.4) | 21.1 (14.1-27.1) | 22.2 (16-39.6) | 0.3 |
Endostatin (ng/ml) | 185 (88-477) | 139 (54-178) | 150 (22-662) | 0.3 |
Endoglin (CD105) (ng/ml) | 3.7 (1.9-5.0) | 3.9 (2.8-5.6) | 3.5 (2.6-5.1) | 0.5 |
Endothelin-1 (pg/ml) | 1.5 (1.0-3.6) | 2.5 (0.9-7.2) | 1.7 (0.4-3.1) | 0.02 |
Angiopoietin-2 (pg/ml) | 2,166 (1241-3,312) | 2,016 (1,249-4,027) | 2202 (1,512-5,148) | 0.5 |
von Willebrand factor antigen (%) | 180 (95-266) | 169 (69-304) | 170 (83-302) | 0.9 |