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Table 3 Association between nailfold videocapillaroscopy patterns and disease characteristics of patients with systemic sclerosis included in the discovery cohort

From: Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis

  NVC pattern P value Multiple linear regression
(r)
P value
  Early/active
(n= 36)
Late
(n= 24)
   
Age, median (range) 58 53 0.2   
Females, n (%) 27 (75) 19 0.9   
Disease duration, median (range) 9.91 7.20 0.2   
Diffuse cutaneous subset, n (%) 13 (36) 11 (46) 0.9   
Modified Rodnan skin score > 14, n (%) 6 (17) 13 (54) 0.005* 0.42 0.0008
History of digital ulcers, n (%) 13 (36) 16 (67) 0.03* 0.25 0.03
Pulmonary fibrosis, n (%) 15 (42) 13 (54) 0.5   
Pulmonary arterial hypertension on RHC, n (%) 2 (6) 2 (8) 0.9   
Positive antitopoisomerase antibodies, n (%) 12 (33) 16 (67) 0.02*   
Positive anticentromere antibodies, n (%) 9 (25) 3 (13) 0.4   
FVC < 75, n (%) 5 (14) 8 (33) 0.1* 0.29 0.01
DLCO/VA < 75%, n (%) 9 (25) 14 (58) 0.02*   
Treatment with angiotensin-converting enzyme inhibitors, n (%) 8 (22) 11 (46) 0.09*   
Treatment with endothelin-receptor antagonists and/or PDE5 inhibitors, n (%) 4 (11) 8 (33) 0.08*   
  1. DLCO/AV, diffusing capacity for carbon monoxide/alveolar volume; FVC, forced vital capacity; NVC, nailfold videocapillaroscopy; PDE5, phosphodiesterase type 5; RHC, right heart catheterization.
  2. * Variables included in multiple regression analysis