Skip to main content

Table 4 Alternate multiple linear regression model performed in the discovery cohort and including both angiogenic factors independently associated with the late-NVC pattern and SSc-related disease characteristics associated univariately with P ≤ 0.10 with the late-NVC pattern

From: Correlations between angiogenic factors and capillaroscopic patterns in systemic sclerosis

  NVC pattern P value Multiple
linear
regression
(r)
P value
  Early/Active
(n = 36)
Late
(n = 24)
   
Modified Rodnan skin score > 14, n (%) 6 (17) 13 (54) 0.005* 0.50 < 0.0001
History of digital ulcers, n (%) 13 (36) 16 (67) 0.03* 0.25 0.04
Positive antitopoisomerase antibodies, n (%) 12 (33) 16 (67) 0.02*   
FVC < 75, n (%) 5 (14) 8 (33) 0.1*   
DLCO/VA < 75%, n (%) 9 (25) 14 (58) 0.02*   
Treatment with angiotensin-converting enzyme inhibitors, n (%) 8 (22) 11 (46) 0.09*   
Treatment with endothelin-receptor antagonists and/or PDE5 inhibitors, n (%) 4 (11) 8 (33) 0.08*   
EPCs (106 Lin-mononuclear cells), median (range) 64 (21-573) 31 (5-300) < 0.0001* -0.45 0.005
VEGF (pg/ml), median (range) 470 (156-1,146) 814 (189-1,564) 0.01* 0.37 0.01
  1. DLCO/AV, diffusing capacity for carbon monoxide/alveolar volume; FVC, forced vital capacity; NVC, nailfold videocapillaroscopy. * Variables included in multiple regression analysis