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Figure 3 | Arthritis Research & Therapy

Figure 3

From: Adenosine A2A receptors promote collagen production by a Fli1- and CTGF-mediated mechanism

Figure 3

Adenosine A 2A receptor occupancy increases CTGF mRNA and protein expression and secretion. NHDF cells were incubated with CGS-26180 at 1 µM A) for 4 hours for CTGF mRNA analysis or B) for 24 hours prior to cellular fractionation and protein concentration from supernates as described under "Methods". Bands were quantified and data represent means ± S.E.M. from three to eight independent experiments. Statistics were performed by one-way ANOVA with post-hoc analysis by Newman-Keuls test, *P <0.05 vs. non-stimulated control.

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