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Table 1 Mutational frequency of Vλ gene rearrangements of B cells from the peripheral blood and from the parotid gland of a patient with Sjögren's syndrome (SS), and of peripheral blood B cells from normal healthy subjects (NHS)

From: Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's syndrome

  SS peripheral blood SS parotid gland NHS peripheral blood
Nonproductive Productive P * Nonproductive Productive P * Nonproductive Productive P *
Overall mutational frequency (%) 0.33†§ 0.97 < 0.001 0.76 3.32 < 0.001 0.60§ 1.12 < 0.001
Mutated Vλ gene rearrangements (n) 14 30   5 24   27 100  
Total Vλ gene rearrangements (n) 27 54   9 29   55 172  
% mutated Vλ gene rearrangements 52 56   55 83   49 58  
  1. * Significant difference between the mutational frequency found in the nonproductive versus the productive Vλ gene repertoire (χ2 test). P < 0.01 and P < 0.001, significant difference between the mutational frequency of the nonproductive and productive, respectively, Vλ gene rearrangements of B cells from the peripheral blood and the parotid gland of a patient with SS. §P < 0.05, significant difference between the mutational frequency of the nonproductive Vλ gene rearrangements of peripheral blood B cells from the patient with SS and of normal donors.