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Table 2 Mutational frequency of Vκ gene rearrangements of B cells from the peripheral blood and from the parotid gland of a patient with Sjögren's syndrome (SS), and of peripheral blood B cells from normal healthy subjects (NHS)

From: Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's syndrome

  SS peripheral blood SS parotid gland NHS
Nonproductive Productive P * Nonproductive Productive P * Nonproductive Productive P *
Mutational frequency (%) 0.20§ 0.77†‡ < 0.001 0.09 2.35 < 0.001 0.48§ 1.08 < 0.001
Mutated Vκ gene rearrangements (n) 15 21   4 43   55 133  
Total Vκ gene rearrangements (n) 40 39   23 50   232 321  
% mutated Vκ gene rearrangements 38 54   17 86   24 41  
  1. * Significant difference between the mutational frequency found in the nonproductive versus the productive Vκ gene repertoire (χ2 test). P = 0.005 and P < 0.001, significant differences in the mutational frequency of the productive Vκ gene rearrangements of B cells from the peripheral blood compared with the parotid gland of a patient with SS or with normal donors. §P < 0.001, significant difference between the mutational frequency of the nonproductive Vκ gene rearrangements of peripheral blood B cells from the patient with SS and of normal donors.