|
Vλ
|
SS peripheral blood productively rearranged genes
|
SS parotid gland productively rearranged genes
|
Comparison of R/S ratios, P*
|
NHS peripheral blood productively rearranged genes
|
|---|
|
FR1
|
1/2 (0.5)
|
7/3 (2.3)
|
ns
|
9/5 (1.8)
|
|
CDR1
|
18/3 (6.0)
|
33/9 (3.7)
|
ns
|
55/14 (3.9)
|
|
FR2
|
19/8 (2.4)
|
34/13 (2.6)
|
ns
|
51/29 (1.8)
|
|
CDR2
|
22/2(11.0)
|
26/7 (3.7)
|
ns
|
48/10 (4.8)
|
|
FR3
|
16/8 (2.0)
|
29/29 (1.0)
|
ns
|
66/28 (2.4)
|
|
CDR3
|
18/6 (3.0)
|
23/6 (3.8)
|
ns
|
81/22 (3.7)
|
|
CDR
|
58/11 (5.3)
|
82/22 (3.7)
|
ns
|
184/46 (4.0)
|
|
FR
|
36/18 (2.0)
|
70/45 (1.6)
|
ns
|
126/62 (2.0)
|
|
Total Vλ
|
gene 94/29 (3.2)
|
152/67 (2.3)
|
ns
|
310/108 (2.9)
|
- Because of the small number of mutations exhibited by nonproductively rearranged Vλ genes of B cells from the parotid gland and from the peripheral blood, only productive Vλ rearrangements were analyzed. FR, framework regions; CDR, complementary determining regions. * Statistical difference between the R/S ratio of productively rearranged Vλ genes from the parotid gland versus peripheral blood from a patient with SS (ns, not significant).
