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Table 3 Replacement to silent ratio (R/S ratio) of productive Vλ gene rearrangements of B cells from the peripheral blood and from the parotid gland of a patient with Sjögren's syndrome (SS), and of peripheral blood B cells from normal healthy subjects (NHS)

From: Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's syndrome

SS peripheral blood productively rearranged genes SS parotid gland productively rearranged genes Comparison of R/S ratios, P* NHS peripheral blood productively rearranged genes
FR1 1/2 (0.5) 7/3 (2.3) ns 9/5 (1.8)
CDR1 18/3 (6.0) 33/9 (3.7) ns 55/14 (3.9)
FR2 19/8 (2.4) 34/13 (2.6) ns 51/29 (1.8)
CDR2 22/2(11.0) 26/7 (3.7) ns 48/10 (4.8)
FR3 16/8 (2.0) 29/29 (1.0) ns 66/28 (2.4)
CDR3 18/6 (3.0) 23/6 (3.8) ns 81/22 (3.7)
CDR 58/11 (5.3) 82/22 (3.7) ns 184/46 (4.0)
FR 36/18 (2.0) 70/45 (1.6) ns 126/62 (2.0)
Total Vλ gene 94/29 (3.2) 152/67 (2.3) ns 310/108 (2.9)
  1. Because of the small number of mutations exhibited by nonproductively rearranged Vλ genes of B cells from the parotid gland and from the peripheral blood, only productive Vλ rearrangements were analyzed. FR, framework regions; CDR, complementary determining regions. * Statistical difference between the R/S ratio of productively rearranged Vλ genes from the parotid gland versus peripheral blood from a patient with SS (ns, not significant).