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Table 3 Replacement to silent ratio (R/S ratio) of productive Vλ gene rearrangements of B cells from the peripheral blood and from the parotid gland of a patient with Sjögren's syndrome (SS), and of peripheral blood B cells from normal healthy subjects (NHS)

From: Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's syndrome

SS peripheral blood productively rearranged genes

SS parotid gland productively rearranged genes

Comparison of R/S ratios, P*

NHS peripheral blood productively rearranged genes

FR1

1/2 (0.5)

7/3 (2.3)

ns

9/5 (1.8)

CDR1

18/3 (6.0)

33/9 (3.7)

ns

55/14 (3.9)

FR2

19/8 (2.4)

34/13 (2.6)

ns

51/29 (1.8)

CDR2

22/2(11.0)

26/7 (3.7)

ns

48/10 (4.8)

FR3

16/8 (2.0)

29/29 (1.0)

ns

66/28 (2.4)

CDR3

18/6 (3.0)

23/6 (3.8)

ns

81/22 (3.7)

CDR

58/11 (5.3)

82/22 (3.7)

ns

184/46 (4.0)

FR

36/18 (2.0)

70/45 (1.6)

ns

126/62 (2.0)

Total Vλ

gene 94/29 (3.2)

152/67 (2.3)

ns

310/108 (2.9)

  1. Because of the small number of mutations exhibited by nonproductively rearranged Vλ genes of B cells from the parotid gland and from the peripheral blood, only productive Vλ rearrangements were analyzed. FR, framework regions; CDR, complementary determining regions. * Statistical difference between the R/S ratio of productively rearranged Vλ genes from the parotid gland versus peripheral blood from a patient with SS (ns, not significant).