Table 4 Replacement to silent ratio (R/S ratio) of productive Vκ gene rearrangements of B cells from the peripheral blood and from the parotid gland of a patient with Sjögren's syndrome (SS), and of peripheral blood B cells from normal healthy subjects (NHS)
Vκ | SS peripheral blood productively rearranged genes | SS parotid gland productively rearranged genes | Comparison of R/S ratios, P* | NHS peripheral blood productively rearranged genes |
|---|---|---|---|---|
FR1 | 0/0 (nd) | 2/2 (1.0) | nd | |
CDR1 | 17/3 (5.7) | 52/14 (3.7) | ns | (4.7) |
FR2 | 5/2 (2.5) | 23/15 (1.5) | ns | (1.3) |
CDR2 | 8/0 (nd) | 31/6 (5.2) | ns | (5.4) |
FR3 | 9/6 (1.5) | 30/28 (1.1) | ns | (1.4) |
CDR3 | 15/4 (3.8) | 23/9 (2.55) | ns | (5.0) |
CDR | 40/7 (5.7) | 106/29 (3.7) | ns | 345/70 (4.9) |
FR | 14/8 (1.8) | 55/45 (1.2) | ns | 195/144 (1.4) |
Total Vκ | gene 54/15 (3.6) | 161/74 (2.2) | ns | 540/214 (2.5) |