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Table 4 Replacement to silent ratio (R/S ratio) of productive Vκ gene rearrangements of B cells from the peripheral blood and from the parotid gland of a patient with Sjögren's syndrome (SS), and of peripheral blood B cells from normal healthy subjects (NHS)

From: Analysis of immunoglobulin light chain rearrangements in the salivary gland and blood of a patient with Sjögren's syndrome

SS peripheral blood productively rearranged genes SS parotid gland productively rearranged genes Comparison of R/S ratios, P* NHS peripheral blood productively rearranged genes
FR1 0/0 (nd) 2/2 (1.0) nd  
CDR1 17/3 (5.7) 52/14 (3.7) ns (4.7)
FR2 5/2 (2.5) 23/15 (1.5) ns (1.3)
CDR2 8/0 (nd) 31/6 (5.2) ns (5.4)
FR3 9/6 (1.5) 30/28 (1.1) ns (1.4)
CDR3 15/4 (3.8) 23/9 (2.55) ns (5.0)
CDR 40/7 (5.7) 106/29 (3.7) ns 345/70 (4.9)
FR 14/8 (1.8) 55/45 (1.2) ns 195/144 (1.4)
Total Vκ gene 54/15 (3.6) 161/74 (2.2) ns 540/214 (2.5)
  1. Because of the small number of mutations exhibited by nonproductively rearranged Vκ genes of B cells from the parotid gland and from the peripheral blood, only productive Vκ rearrangements were analyzed. FR, framework regions; CDR, complementary determining regions. * Statistical difference between the R/S ratio of productively rearranged Vκ genes from the parotid gland versus peripheral blood from a patient with SS (nd, not determined; ns, not significant).