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Figure 4 | Arthritis Research & Therapy

Figure 4

From: Transient anabolic effects accompany epidermal growth factor receptor signal activation in articular cartilage in vivo

Figure 4

Localization of Sox9, SZP and GDF-5. Sections of the tibial articular cartilage of 12-week-old normal Mig-6-flox (A, C, E) and Mig-6-flox;Prx1Cre conditional knockout (Mig-6-cko) knees (B, D, F) immunostained with antibodies against Sox9 (A, B); superficial zone protein (SZP, C, D); and growth and differentiation factor-5 (GDF5, E, F). In normal articular cartilage, immunostaining is localized to cells mainly in the superficial zone (arrows in A, C, E) while in Mig-6-cko articular cartilage, immunostaining is dramatically increased and positive cells are located not only in the superficial zone but also in deeper zones (arrows in B, D, F). Scale Bar = 50 μm (A-D); 25 μM (E, F).

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Arthritis Research & Therapy

ISSN: 1478-6362

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