Prevalence of diffusing lung capacity for carbon monoxide impairment and systemic sclerosis marker autoantibody positivity. (A) Prevalence of diffusing lung capacity for carbon monoxide (DLCO) impairment (<80% of the predicted value) in the 71 early systemic sclerosis (SSc) patients from both centers, divided into three subsets according to the SSc marker autoantibody status and the nailfold videocapillaroscopy (NVC) pattern: presence of both SSc marker autoantibodies and NVC scleroderma pattern (subset 1), presence of SSc marker autoantibodies only (subset 2), and presence of NVC scleroderma pattern only (subset 3). (B) Prevalence of general SSc marker autoantibody positivity and (C) prevalence of either anticentromere antibody (ACA) or other SSc marker autoantibody positivity in all patients from both centers divided according to the presence/absence of DLCO impairment. Chi-square test was applied for statistical analysis of data reported in (A). Fisher's exact test was applied for statistical analyses of data reported in (B) and (C). Abs, autoantibodies.