Serum levels of fibroblast, endothelial, and T-cell activation markers. Serum levels of (A) fibroblast (carboxyterminal telopeptide of type I collagen (ICTP)), (B) endothelial (soluble E-selectin (sE-selectin)), and (D) T-cell (soluble IL-2 receptor alpha (sIL2Rαa)) activation markers in 25 controls affected by ostheoarthritis or fibromyalgia, and 44 early systemic sclerosis (SSc) patients, divided into three subsets according to the SSc marker autoantibody status and the nailfold videocapillaroscopy (NVC) pattern: presence of both SSc marker autoantibodies and NVC scleroderma pattern (subset 1), presence of SSc marker autoantibodies only (subset 2), and presence of NVC scleroderma pattern only (subset 3). (C) Serum levels of sE-selectin in all patients from both centers divided according to the presence/absence of puffy fingers. Kruskal-Wallis test and Mann-Whitney U test were applied for statistical analysis of data reported in (A), (B), and (D). Mann-Whitney U test was applied for statistical analysis of data reported in (C).