Figure 2From: Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapyRho GTPase signaling in chondrocyte development and maturation. Rac1/Cdc42 and RhoA/ROCK signaling pathways are all required for chondrogenesis, and have antagonistic effects on chondrocyte terminal differentiation, which is probably mediated by interaction with Sox9 and Runx2.Back to article page