From: Peripheral regulatory cells immunophenotyping in Primary Sjögren's Syndrome: a cross-sectional study
Variable | Control (n= 25) | All pSS patients (n= 50) | Clinically active pSS patients (n= 17) | Clinically inactive pSS patients (n= 33) | Serologically active pSS patients (n= 29) | Serologically inactive pSS patients (n= 18) | Clinically and serologically active pSS patients (n= 12) | Clinically active and serologically inactive pSS patients (n= 4) | Clinically inactive and serologically active pSS patients (n= 17) | Clinically and serologically inactive pSS patients (n= 14) |
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Demographic | ||||||||||
Age (years) Mean ± SD Median Range | 49.1 ± 11.0 48.5 23 to 75 | 53.1 ± 12.2 53.0 30 to 77 | 50.4 ± 11.8 48.5 30 to 73 | 54.4 ± 12.4 53.0 33 to 77 | 51.1 ± 10.0 50.0 33 to 73 | 55.1 ± 14.6 56.0 30 to 77 | 50.6 ± 10.7 48.0 33 to 73 | 51.5 ± 17.3 52.0 30 to 72 | 51.8 ± 10.3 51.5 33 to 72 | 56.2 ± 14.3 58.0 34 to 77 |
Sex (female/male) | 20/5 | 48/2 | 16/1 | 32/1 | 28/1 | 17/1 | 12/0 | 3/1 | 16/1 | 14/0 |
Clinical | ||||||||||
SSDAI Mean ± SD Median Range | 0.9 ± 1.5 0.0 0 to 6 | 2.5 ± 1.6 3.0 0 to 6 | 0.1 ± 0.3 0.0a 0 to 1 | 1.3 ± 1.7 1.0 0 to 6 | 0.4 ± 0.85 0.0 0 to 3 | 2.8 ± 1.6 3.0 1 to 6 | 1.5 ± 1.3 1.5 0 to 3 | 0.2 ± 0.4 0.0 0 to 1 | 0.1 ± 0.3 0.0 0 to 1 | |
ESSSDAI Mean ± SD Median Range | 1.5 ± 1.3 1.0 0 to 5 | 2.6 ± 1.2 2.0 1 to 5 | 0.9 ± 0.9 1.0 a 0 to 3 | 2.0 ± 1.1 2.0 1 to 5 | 0.4 ± 0.9 0.0 0 to 3 | 2.8 ± 1.2 2.5 1 to 5 | 1.8 ± 1.0 1.5 1 to 3 | 1.5 ± 0.6 1.0 1 to 3 | 0.0 ± 0.0 0.0d 0 to 0 | |
Laboratory | ||||||||||
ESR (mm Hg) Mean ± SD Median Range | 21.3 ± 16.3 15.0 2 to 73 | 23.9 ± 15.7 22.0 2 to 59 | 19.5 ± 16.9 14.0 4 to 73 | 28.6 ± 18.0 26.0 6 to 73 | 12.1 ± 8.4 9.5b 2 to 29 | 29.8 ± 14.6 27.0 8 to 59 | 7.0 ± 3.4 8.5c 2 to 9 | 27.3 ± 21.8 16.0 6 to 73 | 13.8 ± 8.9 12.5 4 to 29 | |
Serum IgM (mg/dL) Mean ± SD Median Range | 208.1 ± 169.8 178.5 28 to 1170 | 186.1 ± 70.2 179.5 52 to 303 | 219.8 ± 204.3 178.5 28 to 1170 | 204.3 ± 90.1 186.0 70 to 553 | 214.6 ± 258.4 146.0 28 to 1170 | 198.3 ± 65.5 201.0 96 to 303 | 149.5 ± 80.9 148.0 52 to 250 | 208.5 ± 105.9 182.0 70 to 553 | 234.6 ± 292.5 137.0 28 to 1,170 | |
Serum IgG (mg/dL) Mean ± SD Median Range | 1779.8 ± 703.9 1,554.0 639 to 3,224 | 1973.4 ± 782.2 1,948.0 825 to 3,029 | 1676.6 ± 648.6 1,531.0 639 to 3,324 | 2092.1 ± 690.9 2,087.0 674 to 3,224 | 1247.1 ± 282.6 1,310.0b 639 to 1,738 | 2261.7 ± 678.5 2,461.0 1,177 to 3,029 | 1108.5 ± 203.7 1,149.5c 825 to 1,310 | 1972.4 ± 694.4 2,028.0 674 to 3,224 | 1289.8 ± 296.2 1,330.0d 639 to 1,738 | |
Serum IgA (mg/dL) Mean ± SD Median Range | 345.7 ± 211.6 305.0 128 to 1420 | 394.1 ± 319.9 290.5 147 to 1420 | 319.9 ± 120.8 308.5 128 to 584 | 396.9 ± 248.9 343.0 128 to 1,420 | 258.5 ± 68.9 259.0 147 to 419 | 446.6 ± 355.8 337.0 176 to 1,420 | 236.8 ± 60.3 261.5 147 to 277 | 361.8 ± 135.0 353.0 128 to 584 | 265.2 ± 72.2 240.0 175 to 419 | |
Serum hyperviscosity (AU) Mean ± SD Median Range | 2.0 ± 0.5 1.9 1.6 to 4.3 | 2.2 ± 0.6 2.1 1.7 to 4.3 | 1.9 ± 0.3 1.8 1.6 to 2.5 | 2.2 ± 0.5 2.1 1.7 to 4.3 | 1.8 ± 0.1 1.8b 1.6 to 2.0 | 2.3 ± 0.7 2.2 1.7 to 4.3 | 1.8 ± 0.2 1.7c 1.7 to 2.0 | 2.0 ± 0.3* 1.9 1.7 to 2.5 | 1.8 ± 0.1 1.8d 1.6 to 2.0 | |
C3 (mg/dL) Mean ± SD Median Range | 96.4 ± 23.6 92.6 53 to 147 | 92.1 ± 24.5 91.5 53 to 135 | 98.3 ± 23.3 92.9 60 to 147 | 88.5 ± 22.3 81.4 53 to 143 | 108.7 ± 19.9 105.8b 77 to 147 | 88.7 ± 26.5 83.4 53 to 135 | 103.2 ± 14.2 99.0 92 to 119 | 88.4 ± 20.4 81.4 60 to 143 | 110.1 ± 21.3 106.4d 77 to 147 | |
C4 (mg/dL) Mean ± SD Median Range | 19.8 ± 6.8 19.0 2 to 33 | 18.6 ± 9.6 19.1 2 to 33 | 20.3 ± 5.3 18.9 11 to 33 | 17.7 ± 6.8 18.6 2 to 33 | 23.6 ± 5.4 24.0c 15 to 33 | 16.8 ± 10.2 18.5 2 to 33 | 24.4 ± 4.6 26.0 19 to 25 | 18.3 ± 4.0 18.6 11 to 51 | 23.4 ± 5.7 24.0 15 to 33 | |
Leucocytes (cells/μL) Mean ± SD Median Range | 6.4 ± 1.3 6.3 4.7--8.5 | 5.7 ± 2.0 5.5 1.5 to 12.6 | 5.6 ± 2.7 5.4 1.5 to 12.6 | 5.7 ± 1.7 5.7 3.0 to 10.7 | 5.1 ± 1.6 5.2 1.5 to 8.2 | 6.6 ± 2.5 6.2 3.9 to 12.6 | 4.8 ± 1.9 4.7 1.5 to 8.1 | 8.4 ± 3.4 7.8 5.2 to 12.6 | 5.4 ± 1.3 5.6 3.0 to 8.2 | 6.2 ± 2.0 6.0 3.9 to 10.7 |
Hemoglobin (g/dL) Mean ± SD Median Range | 14.9 ± 0.8 14.9 13.3--16.5 | 13.9 ± 1.4 14.1 9.9 to 17.8 | 14.4 ± 1.3 14.0 12.7 to 17.8 | 13.7 ± 1.4 14.1 9.9 to 15.9 | 13.9 ± 1.1 14.0 12.1 to 15.9 | 14.1 ± 1.8 14.5 9.9 to 17.8 | 13.9 ± 0.7 14.0 12.7 to 15.0 | 16.1 ± 1.4 15.8 c 14.9 to 17.8 | 13.8 ± 1.3 14.1 12.1 to 15.9 | 13.6 ± 1.5 14.3 9.9 to 15.1 |
Platelets (cells/μL) Mean ± SD Median Range | 264.2 ± 51.1 225.9 172--331 | 229.1 ± 68.1 229.5 73 to 367 | 233.7 ± 95.6 195.0 73 to 367 | 231.9 ± 50.0 231.0 149 to 357 | 223.9 ± 68.9 222.0 82 to 367 | 228.1 ± 69.3 221.0 73 to 357 | 240.2 ± 98.2 234.5 82 to 367 | 153.0 ± 56.8 172.0c 73 to 195 | 212.4 ± 36.7 222.0 154 to 279 | 249.5 ± 57.5 245.5 149 to 357 |
Lymphocytes (%) Mean ± SD Median Range | 31.1 ± 6.2 32.0 20.3--39.7 | 30.0 ± 10.8 28.0 9.0 to 58.0 | 29.9 ± 12.5 29.3 12.9 to 58 | 30.0 ± 9.9 27.5 9.0 to 52.3 | 31.1 ± 10.2 29.3 13.1 to 58.0 | 27.7 ± 12.3 26.5 9.0 to 52.3 | 33.5 ± 12.5 29.9 13.1 to 58.0 | 19.1 ± 7.3 18.2c 12.9 to 27.0 | 29.5 ± 8.1 28.5 18.2 to 48.0 | 30.2 ± 12.5 27.1 9.0 to 52.3 |
Monocytes (%) Mean ± SD Median Range | 8.0 ± 3.6 7.2 3 to 27 | 8.7 ± 5.2 7.1 5 to 27 | 7.6 ± 2.4 7.2 3 to 14 | 8.3 ± 4.2 7.8 5 to 27 | 7.4 ± 2.1 6.7 4 to 12 | 8.5 ± 6.0 7.1 5 to 27 | 7.9 ± 1.7 8.0 6 to 10 | 8.2 ± 2.4 8.0 5 to 14 | 7.2 ± 2.3 6.7 4 to 12 | |
Polymorphonuclear cells(%) Mean ± SD Median Range | 58.9 ± 11.8 61.9 15.0 to 79.5 | 59.5 ± 15.2 63.0 15.0 to 79.5 | 58.7 ± 9.8 61.7 38.8 to 76.0 | 57.3 ± 11.9 60.4 15.0 to 78.1 | 62.1 ± 12.0 64.4 38.8 to 79.5 | 56.0 ± 16.2 60.4 15.0--78.1 | 70.9 ± 6.9 70.6 63.0 to 79.5 | 58.3 ± 8.0 60.4 40.0 to 68.8 | 59.6 ± 12.2 63.5 38.8 to 76.0 |