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Table 2 Frequency of the minor allele of P2RX7 A1405 G allele in pSS patients and controls

From: Epistasis with HLA DR3 implicates the P2X7 receptor in the pathogenesis of primary Sjögren's syndrome

Cohort Group Number A1405G MAFa Odds ratio (95% CI) P-value
Cohort 1 Controls 136 0.15 1  
  All pSS 114 0.20 1.46 (0.91, 2.34) 0.12
  Seronegative pSS 19 0.07 0.44 (0.13,1.52) 0.22
  Seropositive pSS 95 0.23 1.78 (1.09, 2.92) 0.02
Cohort 2 Controls 534 0.15 1  
  All pSS 281 0.17 1.07 (0.79, 1.45)b 0.64
  Seronegative pSS 82 0.21 1.35 (0.87, 2.10) b 0.18
  Seropositive pSS 199 0.16 0.96 (0.68, 1.36) b 0.83
  1. aMAF, minor allele frequency; bprincipal components adjusted analysis; pSS, primary Sjögren's syndrome.