Clinical correlates of a subset of anti-CENP-A antibodies cross-reacting with FOXE3p53-62 in systemic sclerosis

Table 3 Clinical characteristics of 75 ACA⁺ (>74

Variable	Anti-FOXE3p53-62		P-value
	Positive (n= 40)	Negative (n= 35)
Female, n (%)	38 (95.0)	33 (94.3)	1.000^a
Age at diagnosis, years	37.4 (14.2)	41.5 (13.0)	0.217^b
Disease duration, years	20.3 (11.9)	16.2 (8.5)	0.151^b
Disease subtype, limited, n (%)	37 (92.5)	33 (94.3)	0.757^a
Anti-Ap1-17 IgG, µg/ml	252.50 (954.00)	161.00 (313.00)	0.807^b
Anti-Ap17-30 IgG, µg/ml	9.63 (7.00)	5.23 (7.20)	<0.0001^b
mRss	3.70 (4.20)	4.10 (8.40)	0.533^b
FVC, % of predicted	110.6 (17.0)	103.7 (20.6)	0.201^b
DLCO, % of predicted	76.2 (24.0)	76.6 (24.6)	0.727^b
sPAP, mm Hg	29.00 (14.20)	26.20 (8.20)	0.510^b
ILD, n (%)	8 (20.0)	5 (15.2)	0.590 ^a
PAH, n (%)	5 (12.5)	3 (8.6)	0.719^a
Disease severity score	5.30 (2.70)	5.00 (2.30)	0.570^b
Disease activity index	0.91 (0.91)	1.61 (1.61)	0.038^b
Disease activity index domains
mRss >14 (0.0, 1.0)	0.02 (0.16)	0.03 (0.17)	0.980
Scleredema (0.0, 0.5)	0.11 (0.21)	0.11 (0.21)	0.971
Skin (0.0, 2.0)	0.05 (0.30)	0.10 (0.50)	0.481
Digital necrosis (0.0, 0.5)	0.07 (0.18)	0.04 (0.14)	0.396
Vascular (0.0, 0.5)	0.06 (0.16)	0.06 (0.16)	0.887
Arthritis (0.0, 0.5)	0.07 (0.20)	0.06 (0.16)	0.652
DLCO <80% of predicted (0.0, 0.5)	0.26 (0.25)	0.20 (0.25)	0.282
Heart/lung function (0.0, 2.0)	0.05 (0.31)	0.40 (0.81)	0.015
ESR >30 mm/h (0.0, 1.5)	0.18 (0.50)	0.30 (0.60)	0.380
Low C3 or C4 (0.0, 1.0)	0.05 (0.22)	0.31 (0.50)	0.003

Values are presented as mean (SD) unless otherwise indicated. ^aChi-squared test; ^bMann-Whitney U-test; a P-value <0.05 was considered significant. SSc, systemic sclerosis; ACA, anti-centromere-associated protein antibodies; mRss, modified Rodnan skin score; FVC, forced vital capacity; DLCO, diffusing lung capacity for carbon monoxide; sPAP, systolic pulmonary arterial pressure; ILD, interstitial lung disease assessed by high resolution computed tomography; PAH, pulmonary arterial hypertension (sPAP >35 mm Hg); ESR, erythrocyte sedimentation rate in the first hour. Cardiac involvement was evaluated by electrocardiography, echocardiography and physical examination.

ISSN: 1478-6362