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Table 3 Clinical characteristics of 75 ACA+ (>74

From: Clinical correlates of a subset of anti-CENP-A antibodies cross-reacting with FOXE3p53-62 in systemic sclerosis

Variable Anti-FOXE3p53-62   P-value
  Positive (n= 40) Negative (n= 35)  
Female, n (%) 38 (95.0) 33 (94.3) 1.000a
Age at diagnosis, years 37.4 (14.2) 41.5 (13.0) 0.217b
Disease duration, years 20.3 (11.9) 16.2 (8.5) 0.151b
Disease subtype, limited, n (%) 37 (92.5) 33 (94.3) 0.757a
Anti-Ap1-17 IgG, µg/ml 252.50 (954.00) 161.00 (313.00) 0.807b
Anti-Ap17-30 IgG, µg/ml 9.63 (7.00) 5.23 (7.20) <0.0001b
mRss 3.70 (4.20) 4.10 (8.40) 0.533b
FVC, % of predicted 110.6 (17.0) 103.7 (20.6) 0.201b
DLCO, % of predicted 76.2 (24.0) 76.6 (24.6) 0.727b
sPAP, mm Hg 29.00 (14.20) 26.20 (8.20) 0.510b
ILD, n (%) 8 (20.0) 5 (15.2) 0.590 a
PAH, n (%) 5 (12.5) 3 (8.6) 0.719a
Disease severity score 5.30 (2.70) 5.00 (2.30) 0.570b
Disease activity index 0.91 (0.91) 1.61 (1.61) 0.038b
Disease activity index domains    
mRss >14 (0.0, 1.0) 0.02 (0.16) 0.03 (0.17) 0.980
Scleredema (0.0, 0.5) 0.11 (0.21) 0.11 (0.21) 0.971
Skin (0.0, 2.0) 0.05 (0.30) 0.10 (0.50) 0.481
Digital necrosis (0.0, 0.5) 0.07 (0.18) 0.04 (0.14) 0.396
Vascular (0.0, 0.5) 0.06 (0.16) 0.06 (0.16) 0.887
Arthritis (0.0, 0.5) 0.07 (0.20) 0.06 (0.16) 0.652
DLCO <80% of predicted (0.0, 0.5) 0.26 (0.25) 0.20 (0.25) 0.282
Heart/lung function (0.0, 2.0) 0.05 (0.31) 0.40 (0.81) 0.015
ESR >30 mm/h (0.0, 1.5) 0.18 (0.50) 0.30 (0.60) 0.380
Low C3 or C4 (0.0, 1.0) 0.05 (0.22) 0.31 (0.50) 0.003
  1. Values are presented as mean (SD) unless otherwise indicated. aChi-squared test; bMann-Whitney U-test; a P-value <0.05 was considered significant. SSc, systemic sclerosis; ACA, anti-centromere-associated protein antibodies; mRss, modified Rodnan skin score; FVC, forced vital capacity; DLCO, diffusing lung capacity for carbon monoxide; sPAP, systolic pulmonary arterial pressure; ILD, interstitial lung disease assessed by high resolution computed tomography; PAH, pulmonary arterial hypertension (sPAP >35 mm Hg); ESR, erythrocyte sedimentation rate in the first hour. Cardiac involvement was evaluated by electrocardiography, echocardiography and physical examination.