Figure 4From: Molecular targeting of hepatocyte growth factor by an antagonist, NK4, in the treatment of rheumatoid arthritisAdCMV.NK4 inhibits histopathologic changes. (A) The histologic features of swollen joints 60 days after induction of arthritis in LacZ-treated SKG mice exhibited severe synovitis accompanying massive subsynovial infiltration of neutrophils, lymphocytes and macrophages with villous proliferation of synoviocytes. These pathologic changes were significantly inhibited in NK4-treated SKG mice. Original magnification, ×100; inset, ×400. (B) X-ray bone examination taken 60 days after induction of arthritis revealed severe destruction of ankle joints in LacZ-treated SKG mice. These bone changes were inhibited in NK4-treated SKG mice. (C) The percentage of joints exhibiting mild (white bar), moderate (gray bar) and severe (black bar) pathologic changes by AdCMV.NK4-treated SKG mice (n = 8) or AdCMV.LacZ-treated SKG mice (n = 8) 60 days after induction of arthritis.Back to article page