Figure 5From: Molecular targeting of hepatocyte growth factor by an antagonist, NK4, in the treatment of rheumatoid arthritisAdCMV.NK4 inhibits inflammatory cell infiltration, as well as cytokine and RANKL expression, in the synovial tissues of SKG mice. Immunohistochemistry of interleukin 1 (IL-1) (A), IL-6 (B), TNF-α (C), CD31 (D), IL-17 (E) and RANKL (receptor activator of nuclear factor κB ligand) (F). High-level expression of IL-1, IL-6, TNF-α, CD31, IL-17 and RANKL in the synovial tissues of LacZ-treated SKG mice was observed (upper). In contrast, the expression was significantly inhibited in the synovial tissues of NK4-treated SKG mice (lower). Original magnification, ×200.Back to article page