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Figure 2 | Arthritis Research & Therapy

Figure 2

From: Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytes

Figure 2

Loss of phosphorylation of both LKB1 and AMPKα in human knee osteoarthritic chondrocytes. Lysates of cultured primary human knee chondrocytes (grade I to III) were subjected to western blot analysis with antibodies to phospho-liver kinase B1 (p-LKB1; Ser428) and phospho-AMP-activated protein kinase alpha (p-AMPKα; Thr172), as described in Materials and methods. Data representative of three individual experiments (total of 15 different donors).

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