Figure 2From: Linked decreases in liver kinase B1 and AMP-activated protein kinase activity modulate matrix catabolic responses to biomechanical injury in chondrocytesLoss of phosphorylation of both LKB1 and AMPKα in human knee osteoarthritic chondrocytes. Lysates of cultured primary human knee chondrocytes (grade I to III) were subjected to western blot analysis with antibodies to phospho-liver kinase B1 (p-LKB1; Ser428) and phospho-AMP-activated protein kinase alpha (p-AMPKα; Thr172), as described in Materials and methods. Data representative of three individual experiments (total of 15 different donors).Back to article page