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Table 3 Autoantibodies to WIBG, GABARAPL2, ZNF706 and PAD4 proteins in patients with early RA

From: New autoantibodies in early rheumatoid arthritis

         WIBG, ZNF706 and GABARAPL2
   Anti-CCP RF PAD4 WIBG ZNF706 GABARAPL2 combination
RA <1 year (n = 124) vs 186 controls (AS, PsA, SLE, SSc, and healthy) Sensitivity (%) 70 68 18.5 33 18.5 23 48
  Specificity (%) 98 nd 91 98 98 96 94
  PPV (%) 96 nd 57 93 85 80 84
  NPV (%) 81 nd 63 69 64 65 73
RA <1 year negative for anti-CCP (n = 37) vs 186 controls (AS, PsA, SLE, SSc, and healthy) Sensitivity (%) 0 24 11 16 11 27 43
  Specificity (%) nd nd 91 98 98 96 94
  PPV (%) nd nd 19 67 50 59 59
  NPV (%) nd nd 84 86 85 87 89
RA <1 year negative for RF (n = 39) vs 186 controls (AS, PsA, SLE, SSc, and healthy) Sensitivity (%) 23 0 10 15 15 28 44
  Specificity (%) 98 nd 91 98 98 96 94
  PPV (%) 69 nd 19 67 60 61 61
  NPV (%) 84 nd 83 85 85 86 89
RA <1 year negative for anti-CCP and RF (n = 28) vs 186 controls (AS, PsA, SLE, SSc, and healthy) Sensitivity (%) 0 0 4 7 11 32 39
  Specificity (%) nd nd 91 98 98 96 94
  PPV (%) nd nd 5 40 43 56 50
  NPV (%) nd nd 86 87 88 90 91
  1. WIBG, within BGCN homolog (Drosophila); GABARAPL2, GABA(A) receptor-associated protein-like 2; ZNF706, zinc finger protein 706; PAD4, peptidyl arginine deiminase 4; RA: rheumatoid arthritis; CCP, cyclic citrullinated peptide; RF, rheumatoid factor; AS, ankylosing spondylitis; PsA, psoriatic arthritis; SLE, systemic lupus eryth ematosus; SSc, systemic sclerosis; PPV, positive predictive value; NPV, negative predictive value; nd, not determined.