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Table 4 Autoantibodies to WIBG, GABARAPL2, ZNF706 peptides in patients with early RA

From: New autoantibodies in early rheumatoid arthritis

        WIBG P22, ZNF706 P1 and GABARAPL2 P15 combination
   Anti-CCP RF WIBG P22 ZNF706 P1 GABARAPL2 P15  
RA <1 year (n = 60) vs 106 controls (AS, PsA, SLE, and healthy) Sensitivity (%) 72 70 30 35 37 45
  Specificity (%) 100 nd 95 100 95 92
  PPV (%) 100 nd 78 100 81 75
  NPV (%) 86 nd 71 73 73 75
RA <1 year negative for anti-CCP (n = 17) vs 106 controls (AS, PsA, SLE, and healthy) Sensitivity (%) 0 29 12 6 23 41
  Specificity (%) nd nd 95 100 95 92
  PPV (%) nd nd 18 10 31 44
  NPV (%) nd nd 87 86 88 91
RA <1 year negative for RF (n = 17) vs 106 controls (AS, PsA, SLE, and healthy) Sensitivity (%) 29 0 12 12 18 35
  Specificity (%) 100 nd 95 100 95 92
  PPV (%) 100 nd 29 100 37 40
  NPV (%) 90 nd 87 88 88 90
RA <1 year negative for anti-CCP and RF (n = 12) vs 106 controls (AS, PsA, SLE, and healthy) Sensitivity (%) 0 0 8 8 25 42
  Specificity (%) nd nd 95 100 95 92
  PPV (%) nd nd 17 100 37 36
  NPV (%) nd nd 90 91 92 93
  1. WIBG, within BGCN homolog (Drosophila); GABARAPL2, GABA(A) receptor-associated protein-like 2; ZNF706, zinc finger protein 706; RA, rheumatoid arthritis; CCP, cyclic citrullinated peptide; RF, rheumatoid factor; AS, ankylosing spondylitis; PsA, psoriatic arthritis; SLE, systemic lupus eryth ematosus; SSc, systemic sclerosis; PPV, positive predictive value; NPV, negative predictive value; nd, not determined.