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Table 2 Comparison of clinical manifestations in childhood-onset SLE and adult-onset SLE

From: Update on differences between childhood-onset and adult-onset systemic lupus erythematosus

Clinical manifestations Odds ratio 95% confidence interval I2 (%)a
More common in childhood-onset SLE    
   Fever 1.48 1.24 to 1.76 0
   Thrombocytopenia 1.30 1.10 to 1.55 0
   Ulcers/mucocutaneous 1.35 1.13 to 1.61 0
   Urinary cellular casts 2.35 1.68 to 3.29 0
   Seizures 2.32 1.65 to 3.25 16
   Hemolytic anemia 1.90 1.44 to 2.52 17
   Combined IgG and IgM aCL 1.66 1.20 to 2.28 41
More common in adult-onset SLE    
   Sicca 0.42 0.27 to 0.64 0
   Pleuritis 0.69 0.54 to 0.88 0
   Rheumatoid factor 0.53 0.32 to 0.87 0
  1. aCL, anti-cardiolipin antibody; SLE, systemic lupus erythematosus. aI2 statistic was used to examine the between-study heterogeneity. Only disease features with I2 <50% were included in the table.