Figure 4

Multinucleated cells resorbing fat tissue. A, Multinucleated cells in crown-like structure surrounding adipocytes in the synovium of high fat diet (HFD) and chronic antigen induced arthritis (AIA) rabbits (black arrows, hematoxylin and eosin staining, original magnifications x630, scale bar = 25 µm). B, Multinucleated foam cells resorbing adipocytes structures in the synovium of HFD + AIA rabbits (black arrows, hematoxylin and eosin staining, original magnifications x630, scale bar = 25 µm). C, Progression of multinucleated cells presenting from two up to multiple nuclei in the synovium of HFD + AIA rabbits. D, Quantification of multinucleated cells in the synovial membranes of AIA and HFD + AIA rabbits. Bars show the mean and SEM (n = 7 to 9 rabbits per group). E, Circulating synovial cathepsin K-positive multinucleated cells in the proximity of pannus region (original magnification x630, scale bar = 25 µm).